We have identified three novel structures for inhibitors of thepoly(ADP-ribose) polymerase (PARP), a nuclear enzyme activatedby strand breaks in DNA and implicated in DNA repair, apoptosis,organ dysfunction or necrosis. 2-[4-(5-Methyl-1H-imidazol-4-yl)-piperidin-1-yl]-4,5-dihydro-imidazo[4,5,1-i,j]quinolin-6-one(BYK49187), 2-(4-pyridin-2-yl-phenyl)-4,5-dihydro-imidazo[4,...