AIM To study the molecular mechanism of laterally spreading tumor (LST), a cell line [Laterally Spreading Tumor-Rectum 1 (LST-R1)] was derived and the characteristics of this cell line were investigated. METHODS A new cell line (LST-R1) originated from laterally spreading tumor was established. Properties of the cell line were characterized using scanning and transmission electron microscopy,...

Plasmid R1 replication in vitro is inactive in extracts prepared from a dnaK756 strain but is restored to normal levels upon addition of purified DnaK protein. Replication of R1 in extracts of a dnaKwt strain can be specifically inhibited with polyclonal antibodies against DnaK. RepA-dependent replication of R1 in dnaK756 extracts supplemented with DnaKwt protein at maximum concentration is par...

Hormonal stress response is associated with the pathogenesis of disease, including cancer. The role of the stress hormone CRH (corticotropin-releasing hormone) in breast cancer is complex, and its abundance and biological activity may be modulated by estrogen. In the estrogen receptor-positive (ER+) malignant mammary epithelial cell line MCF7, CRH activated numerous kinases and downstream effec...

Let m be a positive integer and let R1, R2 and B be three disjoint sets of points in the plane such that no three points of R1 ∪ R2 ∪ B lie on the same line and |B| = (m−1)|R1|+m|R2|. Put g = |R1∪R2|. Then there exists a subdivision X1∪X2∪· · ·∪Xg of the plane into g disjoint convex polygons such that (i) |Xi ∩ (R1 ∪ R2)| = 1 for all 1 ≤ i ≤ g; and (ii) |Xi ∩B| = m−1 if |Xi ∩R1| = 1, and |Xi ∩B...

Primary cultures of granule cells (GC) from rat cerebellar cortex were used to determine whether bioelectric activity, via a Ca(2+)/calmodulin-dependent kinase (CaMK) signaling cascade, modulates expression and exon selection in the inositol trisphosphate receptor type 1 (IP(3)R1). IP(3)R1 contains or lacks three exons (S1, S2, and S3) that are regulated in a regionally and temporally specific ...

.......................................................................................................................6 BACKGROUND AND METHODOLOGY .........................................................................8 MOBILE LEARNING FOR TEACHERS .............................................................................10 Responses to technology by AME teachers Mobile phones and teacher...

.......................................................................................................................7 BACKGROUND................................................................................................................8 METHODOLOGY...........................................................................................................11 MOBILE LEARNING INITIATIVES ......

A pigmented yeast R1 with strong tolerance to Hg2+ was isolated. Phylogenetic identification based on the analysis of 26S rDNA and ITS revealed R1 is a Rhodotorula mucilaginosa species. R1 was able to grow in the presence of 80 mg/L Hg2+, but the lag phase was much prolonged compared to its growth in the absence of Hg2+. The maximum Hg2+ binding capacity of R1 was 69.9 mg/g, and dead cells coul...

INTRODUCTION Lichen planus (LP) is a chronic inflammatory disease, where the psychogenic factors seem to play an important role in the pathogenesis. AIM To determine the expression of corticotropin-releasing hormone (CRH) receptor type 1 (CRH-R1) in LP. MATERIAL AND METHODS Thirty-two LP patients and 17 age/gender-matched controls were included in the study. Detailed information about the d...