Monoclonal antibodies (MoAbs) against carcinoembryonic antigen were successfully radiolabeled with 111In, and the radiopharmaceutical was characterized in vitro and in normal and tumor-bearing mice. The 111In-MoAb proved to be stable in vitro and in vivo under normal conditions, although instability could be induced in vitro with large quantities of iron-free transferrin. Animal distribution st...

© I a l Today drugs are almost exclusively manufactured industrially. This has been driven by cost savings, but also by a public mandate of high quality and especially standardization, that is difficult to maintain in a non-industrial setting. On the other hand the same public asks for “personalized”or “precision medicine”(Reza Mirnezami et al. 2012) precisely tailored to each patient’s require...

Neuroblastoma (NB) represents the most common extracranial tumor of childhood. Prognosis is quite variable, ranging from spontaneous regression to aggressive behavior with wide metastatization, high mortality, and limited therapeutic options. Radiotheranostics combines a radiopharmaceutical pair in unique approach, suitable both for diagnosis therapy. For many years, metaiodobenzylguanidine (MI...

An 84-year-old woman underwent a dopamine transporter (DAT) study to investigate a non-levodopa-responsive parkinsonism. A SPECT brain scan was conducted four hours after intravenous administration of 1110 MBq (megabecquerels) equivalent to 30 mCi (millicuries) of 99mTc–TRODAT-1. The study revealed a significant uptake deficit of radiopharmaceuticals in the striatum. The semi-quantitative analy...

T he manufacture of radiopharmaceuticals is dependent on skilled personnel who are cross-trained in several disciplines, and currently too few people have the necessary training. To fill this educational gap, SNMMI is spearheading the development of a Quality Systems Personnel Training Program to cross-train chemists and pharmacists—providing the theoretical knowledge and practical experience n...

OS Radium-223 (Xofigo, Bayer and Algeta) is a boneseeking radiopharmaceutical that patients receive via injection. It is approved by the US Food and Drug Administration (FDA) to relieve pain and prolong survival in patients with metastatic castration-resistant prostate cancer (mCRPC) who have symptomatic evidence of bone metastasis. Because radium-223 selectively targets bone, it is not indicat...

I-131 MIBG scintigraphy is routinely used in the diagnosis of neuroendocrine tumours with high specificity. The radiopharmaceutical is taken up via uptake mechanism and actively transported into storage vesicules. The organs with dense sympathetic innervation such as salivary glands, heart, lachrymal glands, spleen and rarely adrenal medulla are normally visualized with I-131 MIBG. Asymetrical ...

Possible applications of thiophenes in radiopharmaceutical chemistry have been explored. Thiophene for benzene ring substitution was applied to the synthesis of thienyl-[18F]GBR 13119, an analog of the potent and selective dopamine uptake inhibitor [18F]GBR 13119. In vivo regional brain distribution in mice shows essentially identical results for the thienyl and phenyl compounds (striatum/cereb...