The present study compared the dosimetric differences of volumetric modulated arc therapy (VMAT) and 7-field intensity modulated radiation therapy technology (7F-IMRT) in assisted radiotherapy plan after resection of rectal carcinoma. Ten cases of patients at stages II-III of rectal cancer transabdominal resection with postoperative pelvic radiotherapy underwent 7F-IMRT and VMAT radiotherapy pl...

Purpose: In radiotherapy, the proper way to ensure that the dose delivered to a patient is correct and strongly agree with that simulated by his treatment plan currently requires a pre-treatment dosimetric verification. Although this procedure can be realised by using a combined detectorphantom system to monitor the patient plan dose delivered on a phantom, the quality of the entire treatment c...

In view of their superior soft tissue contrast compared to computed tomography, magnetic resonance images are commonly involved in stereotactic radiosurgery/radiotherapy applications for target delineation purposes. It is known, however, that magnetic resonance images are geometrically distorted, thus deteriorating dose delivery accuracy. The present work focuses on the assessment of geometric ...

The construction of the American Psychiatric Association's diagnostic manual has been guided primarily by concerns of construct validity rather than of clinical utility, despite claims by its authors that the highest priority has in fact been clinical utility. The purpose of this article was to further articulate the concept and importance of utility when constructing and evaluating a diagnosti...

Cyclic AMP stimulates translocation of Na(+)/taurocholate cotransporting polypeptide (NTCP) from the cytosol to the sinusoidal membrane and multidrug resistance-associated protein 2 (MRP2) to the canalicular membrane. A recent study suggested that protein kinase Cδ (PKCδ) may mediate cAMP-induced translocation of Ntcp and Mrp2. In addition, cAMP has been shown to stimulate NTCP translocation in...

Implant surgery complications are frequent occurrences in dental practice and knowledge in the management of these cases is essential. The aim of this review was to highlight the challenges of treatment plan-related, anatomy-related, and procedure-related surgical complications as well as to discuss the etiology, management and treatment options to achieve a satisfactory treatment outcome.

Background: Our aim was to analyze the effects of set-up errors on dose distribution in radiotherapy treatment for lung cancer by using kilovoltage cone-beam CT (CBCT). Materials and Methods: In this study, we used a Varian IX linear accelerator system perform CBCT scans 30 patients before radiotherapy. Subsequently, image matched with planned CT, left right (LR), top bottom (SI), front back (A...

The human Na(+)-taurocholate cotransporting polypeptide (Ntcp) is located exclusively on the basolateral membrane of hepatocyte, but the mechanisms underlying its membrane sorting domain have not been fully elucidated. In the present study, a green fluorescent protein-fused human NTCP (NTCP-GFP) was constructed using the polymerase chain reaction and was stably transfected into Madin-Darby cani...

The sodium taurocholate cotransporting polypeptide (Ntcp) is the major uptake transporter for bile salts into liver parenchymal cells, and PKC-mediated endocytosis was shown to regulate the number of Ntcp molecules at the plasma membrane. In this study, mechanisms of Ntcp internalization were analyzed by flow cytometry, immunofluorescence, and Western blot analyses in HepG2 cells. PKC activatio...

BACKGROUND AND PURPOSE To assess the effect of differences in the calculation of the dose outside segment edges on the overall dose distribution and the optimisation process of intensity modulated radiation therapy (IMRT) treatment plans. PATIENTS AND METHODS Accuracy of dose calculations of two treatment planning systems (TPS1 and TPS2) was assessed, to ensure that they are both suitable for...