A mathematical computer model of frog Purkinje cells is generated on the basis of presentday morphological and physiological data. The mode1 utilizes passive cable equations and the Hodgkin & Huxley equations describing ionic conductances in excitable membranes. It comprises 62 compartments, the active and passive properties being specified independently for each compartment. The morphological ...

Can an electronic portfolio that is both a multimedia container for student work and a tool to support key learning processes have a positive impact on the literacy practices and self-regulated learning skills of students? This article presents the findings of a yearlong study conducted in three Canadian provinces during the 2007–2008 school year initially involving 32 teachers and 388 students...

The suspect of muscular dystrophy may cause anxiety and stress among those affected and their family members. When a definite diagnosis is obtained, the scenario may be very different depending on the genetic cause. This is particularly true in the case of limb-girdle muscular dystrophies, where clinical heterogeneity among and within forms is extreme (1). In the case of Duchenne muscular dystr...

A computer model of the hippocampal pyramidal cell (HPC) is described which integrates data from a variety of sources in order to develop a consistent description for this cell type. The model presently includes descriptions of eleven non-linear somatic currents of the HPC, and the electrotonic structure of the neuron is modelled with a soma/short-cable approximation. Model simulations qualitat...

Experimental validation of a theoretical prediction by measurements has often produced a critical step forward in our understanding of brain function. Donald Hebb’s original idea that the repetitive contribution of cell A to cell Bs fi ring should result in a strengthening of this particular connection was spectacularly confi rmed by the discovery of spike timing dependent plasticity (STDP; Bi ...

Myreflections cover my scientific work over a sixty-year period. At the University of Michigan, I was initially interested in embryology. In medical school in the army, I became entranced with biochemistry and DeWitt Stetten, who introduced me to Carl Cori. Carl along with Gerty Cori and Earl Sutherland became my scientific mentors. After medical school and a nine-month medical internship, I re...

As we move into the next millennium, the importance of environmental health issues escalates. While humans always had an impact on their environment, the destructive impact began to mount with the advent of the Industrial Revolution and continued throughout the 19th century. As the 20th century comes to a close, soaring world population, overconsumption, and waste production have led to an enor...

INTRODUCTION Mass Storage as a functional need in computer systems is continually increasing in importance with the growing trend to interactive terminal-oriented systems, serving as peripheral or external on-line memory for storing a systems data base and resident programming systems. The associated capacity, plus the ever expanding magnitude of such data, far exceeds the range where "electron...

Hoffmann originally described how an electric shock to the tibial nerve in man evokes not only a motor response in the calf muscles but also a wellsynchronized reflex response with a latency of about 30 msec. This late response, which he identified with the stretch reflex, was shown to have the following characteristics (Hoffmann, 1918, 1922; Hoffmann and Keller, 1928): (a) It appears only in m...

This note introduces at, English-to-Korean Machiue 'lYanslation System MA!t'ES/EK, which ha.s been developed as a research prototype and is still under upgrading in KAIST (Korea Advanced Institute of Science and Technology). MATES/EK is a transfl:r.-ba.~ed system and it has several subsystems tt, at can be used to support other MT-developments. They are gram-. mar developing environment systems...