نتایج جستجو برای: ranolazine
تعداد نتایج: 610 فیلتر نتایج به سال:
INTRODUCTION Fever can increase the susceptibility to supraventricular and ventricular arrhythmias, in which sodium channel dysfunction has been implicated. Whether fever influences the efficacy of sodium channel blocking drugs is unknown. The current study was designed to investigate the temperature dependent effects of distinct sodium channel blocking drugs on the sodium currents in human ind...
Chronic stable angina is a debilitating illness affecting millions worldwide. Considerable progress has been made over the last 30 years in the understanding of the pathogenesis of angina pectoris. Over the period, number of pharmacological measures such as nitrates, beta-Blockers, calcium channel blockers and revascularisation strategies such as Coronary Artery Bypass Grafting (CABG) and Coron...
Background Ranolazine (RAN) is a novel late sodium current inhibitor, effective in treating angina pectoris in patients with chronic stable CAD. Its therapeutic effectiveness is not well understood. It is thought to reduce myocardial energy utilization by enhancing diastolic relaxation and by increasing myocardial blood flow. The purpose of the present study is to define the mechanism for the e...
The negative chronotropic effects of eight Vaughan Williams Class I antiarrhythmic drugs were examined in guinea pig right atrial tissue preparations. decreased the spontaneous beating rate at concentrations overlapping with their therapeutic blood levels. Cibenzoline, aprindine, flecainide, and propafenone showed stronger effects; 10 µM each drug to about 75% initial values. Disopyramide, mexi...
In addition to the hallmark muscle stiffness, patients with recessive myotonia congenita (Becker disease) experience debilitating bouts of transient weakness that remain poorly understood despite years study. We performed intracellular recordings from both genetic and pharmacologic mouse models Becker disease identify mechanism underlying weakness. Our reveal depolarizations (plateau potentials...
This review continues a series of reviews on the analysis compounds with cardioprotective properties in number biaromatic structures, which include range sodium channel blockers. Among voltage-gated channels, Nav1.5 isoform is most abundant heart. Sodium blockers have historically been called "class I antiarrhythmics". this type, structure mainly late current belonging to Id subclass antiarrhyt...
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