Adipokines and other biomarkers were previously identified with roles in energy expenditure, appetite, satiety, and adiposity. Therefore, we investigated whether dietary weight loss-induced changes in adipokines and other biomarkers known to play a role in weight regulation or energy expenditure could predict weight regain in people with overweight and obesity. In this randomized controlled tri...

CONTEXT The aim of this study was to assess the plasma leptin, adiponectin, resistin, visfatin/NAMPT, omentin-1, vaspin, apelin, TNF-α, IL-6 and RBP4 levels in relation to hormonal changes during the menstrual cycle in young, healthy, normal-weight women. METHODS The study involved 52 young, healthy, normal-weight women. Anthropometric parameters, body composition and levels of plasma leptin,...

OBJECTIVE This study aimed to examine possible genetic effects of some retinol binding protein-4 (RBP4) single nucleotide polymorphisms (SNPs) on the risk of gestational diabetes mellitus (GDM). In addition, the SNPs were examined for their possible association with insulin resistance at 6 weeks after delivery. METHODS This was a prospective study of 100 women with GDM and 100 participants wi...

Background: Existing research has shown that retinol binding protein (RBP4) an impairing effect on arterial elasticity and induces insulin resistance, but the clinical value of RBP4 in patients with coronary heart disease (CHD) combined type 2 diabetes mellitus (T2DM) not been investigated. This study sought to compare complexity artery lesions between CHD T2DM those without T2DM, analyze risk ...

Hirschsprung disease is a serious disorder of enteric nervous system (ENS) development caused by the failure of ENS precursor migration into the distal bowel. We now demonstrate that retinoic acid (RA) is crucial for GDNF-induced ENS precursor migration, cell polarization and lamellipodia formation, and that vitamin A depletion causes distal bowel aganglionosis in serum retinol-binding-protein-...

the established risk factors for cardiometabolic disease. However, the alarming increase in overweight and obesity in children and the trajectory and reach of related comorbidities such as cardiometabolic disease challenge us to identify potential modifiable pathways that will have sufficient impact to turn these around. In this context, this study is a step in the direction of identifying uniq...