نتایج جستجو برای: reactive idiotypes cri

تعداد نتایج: 163657  

Objective(s): Ghrelin is a peptide hormone that has been shown to have numerous central and peripheral effects. The central effects including GH secretion, food intake, and energy homeostasis are partly mediated by Kiss1- KissR signaling pathway. Ghrelin and its receptor are also expressed in the pancreatic islets. Ghrelin is one of the key metabolic factors controlling insulin secretion from t...

Journal: :Blood 1986
F K Stevenson M Wrightham M J Glennie D B Jones A R Cattan T Feizi T J Hamblin G T Stevenson

Monoclonal anti-idiotypic antibodies generated against idiotypic immunoglobulin (Ig) of neoplastic B lymphocytes can be selected from growing hybridoma clones by their ability to recognize idiotypic but not normal IgM. This group of antibodies can be subdivided into those that bind to the target tumor cells in the presence of normal human serum (approximately 85% of the clones) and those in whi...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1989
K Meek B Johansson J Schulman C Bona J D Capra

We have generated four monoclonal antibodies specific for one or more members of a series of two sequentially derived PR8 influenza virus variants. Three of these antibodies share cross-reactive idiotypes. The amino acid sequences of these antibodies were determined, and it was found that two of these antibodies use genes from the VH7183 family, whereas the third uses a gene from the VHJ558 fam...

Journal: :Orphanet Journal of Rare Diseases 2006
Paola Cerruti Mainardi

The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromosome 5 (5p-). The incidence ranges from 1:15,000 to 1:50,000 live-born infants. The main clinical features are a high-pitched monochromatic cry, microcephaly, broad nasal bridge, epicanthal folds, micrognathia, abnormal dermatoglyphics, and severe psychomotor and m...

Journal: :Annals of the rheumatic diseases 1990
F Shokri R A Mageed E Tunn P A Bacon R Jefferis

Monoclonal rheumatoid factors (RFs) of the major Wa cross reactive idiotype group have been shown to express exclusively VKIII subgroup light chains and VHI subgroup heavy chains. A VKIII associated cross reactive idiotope (CRI) (17-109), however, was shown not to be exclusively expressed on IgM paraproteins having rheumatoid factor activity or to be present at increased levels in the sera of p...

Journal: :Journal of endourology 2011
Matvey Tsivian Jorge Caso Masaki Kimura Thomas J Polascik

BACKGROUND AND PURPOSE Laparoscopic cryoablation (LCA) has emerged as an alternative to conventional surgery for the management of a T(1) renal mass; however, only few data are available on its functional outcomes. We assessed renal function changes after LCA in patients with normal renal function (NRF) and preexisting chronic renal insufficiency (CRI). PATIENTS AND METHODS Data of consecutiv...

Journal: :Drug metabolism and disposition: the biological fate of chemicals 2006
Chuanhui Yu Joseph K Ritter Richard J Krieg Bhaskar Rege Thomas H Karnes Mohamadi A Sarkar

Significant evidence exists regarding altered CYP450 enzymes in chronic renal insufficiency (CRI), although none exists for the phase II enzymes. The objective of this study was to investigate the effect of CRI on hepatic and renal UDP-glucuronyltransferase (UGT) enzymes. Three groups of rats were included: CRI induced by the 5/6th nephrectomy model, control, and control pair-fed (CPF) rats. UG...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011
Jae-Woo Jung Woo-Jung Song Yon-Su Kim Kwon Wook Joo Kyung Wha Lee Sae-Hoon Kim Heung-Woo Park Yoon-Seok Chang Sang-Heon Cho Kyung-Up Min Hye-Ryun Kang

BACKGROUND Although allopurinol is a very effective urate-lowering drug for complicated hyperuricemia, in some patients, it can induce severe cutaneous adverse reactions (SCARs). Recent investigations suggest that HLA-B*5801 is a very strong marker for allopurinol-induced SCARs, especially in the population with a high frequency of HLA-B*5801. Korea is one of the countries with a high frequency...

2015
Yu Jie Chen Ling Xiao Chen Mei Xiang Han Tian Song Zhang Zhi Rui Zhou Dian Sheng Zhong Wang. Lu

Chemotherapy plays a critical and venturous role against the co-morbidity of nonsmall cell lung cancer and interstitial lung disease (NSCLC-ILD).We performed a Bayesian meta-analysis and systematic review to evaluate the safety and efficacy of the chemotherapy in NSCLC-ILD patients.EMBASE, PubMed, the Cochrane Central Register of Controlled Trials, and clinicaltrials.gov (up to January 2015).We...

Journal: :The American journal of clinical nutrition 2015
Becky L Tsang Owen J Devine Amy M Cordero Claire M Marchetta Joseph Mulinare Patricia Mersereau Jing Guo Yan Ping Qi Robert J Berry Jorge Rosenthal Krista S Crider Heather C Hamner

BACKGROUND The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural tube defects. The T allele produces an enzyme with reduced folate-processing capacity, which has been associated with lower blood folate concentrations. OBJECTIVE We assessed the association between MTHFR C677T genotypes and blood folate concentrations among healthy women aged 12-49 y. ...

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