BACKGROUND Epidemiological evidence supports an important association between air pollution exposure and hypertension. However, the mechanisms are not clear. METHODS AND RESULTS Our present study found that long-term exposure to fine particulate matter (PM2.5) causes hypertension and impairs renal sodium excretion, which might be ascribed to lower D1 receptor expression and higher D1 receptor...

 In recent years, researchers have been looking for genes whose products can directly affect the aging process. Among these, the anti-aging protein klotho has attracted much attention. This single transmembrane protein is expressed in the renal tissues, parathyroid gland and choroid network of the brain and acts as a co-receptor for Fibroblast Growth Factor FGF. In this way, it contributes to c...

Introduction: Association between plasma high-sensitivity C-reactive protein (CRP) concentrations and cardiovascular disease has been Investigated. C-reactive protein (CRP) is an acute phase reactant which is a marker of inflammation in the body. CRP is made by the liver in response to inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα). Adipose ti...

Background. Data on iron and vitamin A deficiency are scarce in school-aged children living with HIV (HIV+) compared without (HIV–). Both deficiencies can contribute to anaemia.
 Objective. To assess anaemia, status a sample of HIV+ HIV– South Africa.
 Methods. In this comparative cross-sectional study, biomarkers for anaemia (haemoglobin), (plasma ferritin (PF), soluble transferrin r...

Nucleotide-binding leucine-rich repeat (NLR) proteins play critical roles in plant immunity. However, how NLRs are regulated and activate defense signaling is not fully understood. The rice (Oryza sativa) NLR receptor Piz-t confers broad-spectrum resistance to the fungal pathogen Magnaporthe oryzae RING-type E3 ligase AVRPIZ-T INTERACTING PROTEIN 10 (APIP10) negatively regulates accumulation. I...

Human oral squamous carcinoma is considered the most common cancer; it imposes multiple and dental consequences as a result of cancer treatment. We previously found that nanoencapsulation cordycepin (CS) could inhibit cells. However, mechanism action was not understood. The aim this study to investigate signaling pathway by which CS encapsulated nanoparticles (NPs) activate inhibition cell grow...

Earlier findings reported the anticancer-mediated activities of curcumin-modified compounds Pentagamavunone-1 (PGV-1) and Chemoprevention Curcumin Analog 1.1 (CCA-1.1) with several mechanisms including cell cycle arrest, reactive oxygen species (ROS) production, migration disruption. Our study aims to evaluate antimigratory activity PGV-1 CCA-1.1 on aggressive breast cancer lines (MDA-MB-231 HC...

BACKGROUND Currently used indicators of iron status have limitations. Hepcidin, a key regulator of iron metabolism, is reduced in iron deficiency. We sought to determine the properties of hepcidin as a diagnostic test of iron deficiency. DESIGN AND METHODS Sera from female, non-anemic, whole blood donors were analyzed for hepcidin (enzyme-linked immunosorbent assay), ferritin, soluble transfe...