Macarbomycin is an antibiotic produced by Streptomyces phaeochromogenes, inhibitory mainly against Gram-positive bacteria including drug-resistant strains and with low toxicity. It is readily soluble in water and relatively stable over a wide pH range. Its antibacterial activity is markedlyreduced by serum albumin. The antibiotic showsa moderatecurative activity to staphylococcal infection in m...

In a previous paper (1), i t was shown tha t strains of pneumococci producing a capsule of soluble polysaccharide (C~) 1 related chemically and immunologically to the C or cell-wall polysaccharide of pneumococcus arise b y spontaneous muta t ion and can be isolated readily from several noncapsulated var iants of this organism. Vaccines of the Cs mutan t s are highly antigenic in rabbits , givin...

can readily determine Fe(II), Mn (II), S(-11) and dissolved 02. Procedures for collecting and handling samples are described and the results from different studies are systematically discussed and evaluated. soluble, colloidal and particulate species have led to the characterization of the time dependent formation of colloidal, complexed and solid phase forms of FeS in natural waters, and to an...

A more sensitive test agar was developed to detect oral microbes with relatively low dextranase activity and to identify dextranase-negative mutants. Several oral streptococci that had previously been scored as dextranase negative readily decolorized the new, blue dextran-containing medium. To assess whether dextranase plays a role in glucan synthesis by oral streptococci, various glucan synthe...

O-benzyl-L-serine carboxyanhydrides were synthesized via diazotization of O-benzyl-L-serine with sodium nitrite in aqueous sulfuric acid solution followed by cyclization of the resulting serine-based α-hydroxy acid with phosgene. Degradable, water-soluble poly(α-hydroxy acids) bearing pendant hydroxyl groups were readily prepared under mild conditions via ring-opening polymerization of O-benzyl...

We have investigated the subcellular distribution and dynamics of soluble tubulin in unperturbed and transfected HeLa cells. Under normal culture conditions, endogenous alpha/beta tubulin is confined to the cytoplasm. However, when the soluble pool of subunits is elevated by combined cold-nocodazole treatment and when constitutive nuclear export is inhibited by leptomycin B, tubulin accumulates...