نتایج جستجو برای: receptors of interleukin
تعداد نتایج: 21189198 فیلتر نتایج به سال:
Background and Aim: Cytokines are believed to play an important role in the regulation of cellular immune response in hepatitis B virus infection. Interleukin 10 is a member of cytokine family. The overall expression of these molecules is mainly controlled by single nucleotide polymorphisms at specific sites on the promoter region of the Interleukin 10 gene. The aim of this study was to a...
This study aimed to more precisely assess the correlation between interleukin-4 (IL-4) promoter polymorphisms and the susceptibility risk of asthma. We conducted association studies on IL-4 promoter C-33T, C-589T, and G-1098T polymorphisms with asthma using data obtained from MEDLINE up to September 2011. Results showed that the polymorphisms IL-4 C-33T and C-589T were significantly associated ...
Viruses are detected by the innate immune system, leading to the initiation of the anti-viral immune response via the production of type I interferons and inflammatory cytokines such as interleukin-1. Remarkable progress has been made over the past few years towards understanding the contribution of Toll-like receptors, RIG-I like receptors, NOD-like receptors and HIN-200 family members to vira...
Several reports demonstrate that interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta), although distantly related at the primary sequence level, bind to the same receptor. This raises the question of what separation, if any, there might be between their biologic activities. Receptor binding assays and cross-competition studies in three Epstein Barr virus (EBV) positive cell lines...
During December 2019 at Wuhan the SARS-CoV-2 epidemic emerged and rapidly occupies entire world, present as pandemic responsible for pulmonary dysfunction like acute respiratory distress syndrome pneumonia but with time clinicians researchers have been found some extrapulmonary features of COVID-19 which may reflect either replication or dissemination infection widespread immunopathological seq...
The most prevalent form of chronic dermatophytoses causing pathogenic fungus in humans is Trichophyton rubrum. Keratinocytes, the main epidermal cells, are crucial local immune interactions because they represent first line defense against microbial assaults, skin In response to varied stimuli, keratinocytes express a wide range receptors and create host peptides, cytokines, chemokines, this im...
Human interleukin (IL)-10 is a pleiotropic cytokine acting on a variety of immune cells. Here we show that the protein can be enzymatically iodinated to high specific radioactivity with retention of biological activity. The radiolabeled ligand binds specifically to its receptor in several mouse and human cell lines, notably human B-lymphoma line JY and mouse mast cell line MC/9. Human IL-10 app...
Intravenous immunoglobulin has long been used in treating autoimmune diseases, although mechanisms remain uncertain. Activating Fcγ receptors are receptors of IgG and reported to be essential in intravenous immunoglobulin (IVIG) therapy. Therefore, we hypothesized natural killer (NK) cells, which express abundant activating Fcγ receptors, are the potential cellular target. In experimental autoi...
Toll-like receptors (TLRs) belong to the Toll-like receptor (TLR)/interleukin-1 receptor (IL-1R) superfamily, which is defined by a common cytoplasmic Toll/interleukin-1 receptor (TIR) domain. These receptors recognize pathogen-associated molecular patterns and initiate an intracellular kinase cascade to cause an immediate defensive response. SIGIRR (single immunoglobulin interleukin-1 receptor...
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