Disturbance of miRNA expression may play a key role in the initiation and progression of colorectal cancer (CRC). CRC should be viewed as a heterogeneous disease, but previous studies have only screened dysregulated miRNAs in CRC from a panel of 96, 145, 287 and 455 miRNAs, respectively. It is necessary to identify new aberrantly expressed miRNAs ...

Rectal cancers have more local relapses than colonic cancers. Since nuclear -catenin plays an important role for the proliferation capacity of cells, we wanted to evaluate whether there may be differences in the expression pattern of nuclear -catenin between rectal and colonic adenocarcinomas, explaining the observations made in clinical practice. Sections from 235 rectal adenocarcinomas treate...

BACKGROUND Surgical margin status is an important predictor of risk of relapse among patients with rectal cancer. METHODS Patients referred to the British Columbia Cancer Agency for consideration of adjuvant therapy for rectal adenocarcinoma were included. Predictors of margin positivity were determined from uni- and multivariate analysis. RESULTS Among 340 patients, 83% had negative resect...

The diagnostic applications for EUS have grown tremendously over the last decade. Most of the early development involved the use of EUS for upper GI indications. Until recently the rectal applications of EUS have largely remained unexplored. Several recent publications have demonstrated the usefulness of EUS in the evaluation of rectal diseases.1-3 At our center, there has been a steady increas...

Rectal chlamydia diagnoses have been increasing among MSM and may also rise among women as anal sex rates increase among heterosexuals. However, there is growing concern about treatment for rectal chlamydia with treatment failures of up to 22% being reported. This article addresses factors that may be contributing to treatment failure for rectal chlamydia, including the pharmacokinetic properti...

A 19 year female came with the complaints of rectal bleeding, constipation, griping abdominal pain and mucous discharge per rectum. Abdomen was tender on examination. Digital rectal examination in the squatting position revealed unterior rectal wall prolapse to the anal verge. Sigmoidoscopy and biopsy confirmed the diagnosis of Solitary Rectal Ulcer (S.R.U.) Syndrome.

Issues concerning the accuracy of hot-wire measurements in turbulent pipe flow are addressed for pipe Reynolds numbers up to 6 × 106 and hot-wire Reynolds numbers up to Rew ≈ 250. These include the optimization of spatial and temporal resolution and the associated feature of signal-to-noise ratio. Very high wire Reynolds numbers enable the use of wires with reduced length-to-diameter ratios com...

We report on the realization and characterization of a magnetic microtrap for ultracold atoms near a straight superconducting Nb wire with circular cross section. The trapped atoms are used to probe the magnetic field outside the superconducting wire. The Meissner effect shortens the distance between the trap and the wire, reduces the radial magnetic-field gradients, and lowers the trap depth. ...

It is shown that the conductance of a weakly disordered Luttinger-liquid quantum wire connected to non-interacting leads is affected by electron-electron interactions in the wire. This is in contrast to the case of a perfect wire the conductance of which is given by e2/h regardless of interactions in the wire. The disorder-induced correction to the conductance scales with temperature and/or the...

OBJECTIVE The floating wire technique is a special technique for solving interventional problems in aorta- ostial lesions. There are no long-term data in the literature for the floating wire technique in right aorto-ostial lesions. METHODS One hundred twenty six patients were retrospectively analyzed in this study. All of these patients had a critical right coronary aorto-ostial lesion. The f...