Seventy-six female patients with two or more recurrent pregnancy losses (RPL) during the 1(st) trimester were studied. Based on the results of the aCL and aB2GPI antibodies testing, patients were divided in two groups: 22 patients with RPL and elevated immunoglobulin (Ig) G/IgM aCL and/or aB2GPI [RPL + antiphospholipid syndrome (APS)] and 54 patients with RPL alone (without high antibodies). Im...

etiologic factors for recurrent miscarriage (rm) include autoimmune diseases, the most frequently antiphospholipid syndrome and thyroiditis. some women who suffer from rm might also have an altered immune system. we aimed to evaluate possible associations between anti-thyroid and anti-phospholipid antibodies in women with rm. in a retrospective case series 1 on 156 women with rm, major outcome ...

OBJECTIVE To identify the associations between polymorphisms of the 3'-untranslated region (UTR) of methylenetetrahydrofolate reductase (MTHFR) gene, which codes for an important regulatory enzyme primarily involved in folate metabolism, and idiopathic recurrent pregnancy loss (RPL) in Korean women. METHODS The study population comprised 369 RPL patients and 228 controls. MTHFR 2572C>A, 4869C...

Introduction Recurrent pregnancy loss (RPL) occurred in ~1-2% of reproductive women. Previous studies have implicated that altered expression and polymorphisms interleukin-related genes might be involved RPL. The aim this study was to explore the potential presence interleukin-22 receptor subunit alpha-2 (IL22RA2) mutations Han Chinese women with unexplained recurrent (URPL). Material methods A...

Recurrent pregnancy loss (RPL) in polycystic ovary syndrome (PCOS), which occurs in ∼50% of total pregnancies is a frequent obstetric complication. Among the several hypotheses, insulin resistance (IR), obesity and hyperhomocysteinemia (HHcy) play significant role/s in RPL. This study was conducted to assess the link between elevated levels of homocysteine and IR in PCOS-associated women with R...

Abstract Background To evaluate the interaction of depression and anxiety with development recurrent pregnancy loss (RPL). Methods A nested case–control study involving 2558 participants was conducted data from prospective Miscarriage Woman Cohort between 2017 2019 in province Gansu, China. The questionnaire data, self-rating scale were collected after each participant’s first miscarriage. Info...

BACKGROUND Cytogenetic analysis of products of conception (POC) is essential for the management of recurrent pregnancy loss (RPL), but the currently-performed G-banding method is not necessarily applicable to spontaneously discharged POC because of poor quality for culture. We analyzed the karyotypes of 15 spontaneously discharged POC by array-based comparative genomic hybridization (array-CGH)...

Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. It has been suggested that women with thrombophilia have an increased risk of pregnancy loss and other adverse pregnancy outcomes. Thrombophilia is an important predisposition to blood clot formation and is cons...

Background: Chlamydia trachomatis infection is widely prevalent sexually transmitted infection. associated with pelvic inflammatory disease, salpingitis, infertility and various adverse pregnancy outcomes example- preterm labour, Premature rupture of membranes, spontaneous miscarriage. Association recurrent loss not yet well understood. The aim the present study was to determine association (RP...