Dr. Helmut Sies (MD, 1967) is recognized as a Redox Pioneer, because he authored five articles on oxidative stress, lycopene, and glutathione, each of which has been cited more than 1000 times, and coauthored an article on hydroperoxide metabolism in mammalian systems cited more than 5000 times (Google Scholar). He obtained preclinical education at the University of Tübingen and the University ...

Plant thioredoxins (Trxs) participate in two redox systems found in different cellular compartments: the NADP-Trx system (NTS) in the cytosol and mitochondria and the ferredoxin-Trx system (FTS) in the chloroplast, where they function as redox regulators by regulating the activity of various target enzymes. The identities of the master regulators that maintain cellular homeostasis and modulate ...

The redox state, like the pH or the osmotic pressure, represents chemical characteristics of the intracellular environment. The intracellular redox homeostasis can be disturbed by the installation of the “oxidative stress”, which manifests itself through the dysregulation of the balance between the systems that produce oxidant agents and the antioxidant defense mechanisms (the redox balance). E...

It has been demonstrated in several model systems that tumors arise in a multistage process. Carcinogenic aromatic amines are complete carcinogens, which usually produce tumors in typical target tissues without any additional treatment. The tissue specificity, however, cannot readily be explained by genotoxic effects, and the role of secondary effects is not well understood. Promotional pressur...

The cyclic voltammetry of both bulk manganese sulfate (BMS) and nano manganese sulfate (NMS) were studied using 0.1M KCl supporting electrolyte and glassy carbon working electrode. The redox behavior for both bulk (BMS) and MnSO4 (NMS) sulfate was studied voltammetrically in presence and absence of Doxorubicin (DR) using three electrodes system, silver- silver chloride (Ag/AgCl), pla...