The CD4 + 25 hi Foxp3 + T regulatory (T-reg) cells are naturally-born in thymus and they are critical for maintaining the tolerance to self and non-self antigens. Foxp3 is the master-regulatory gene of development and function of this cell subset. Using two mouse strains that share the same MHC class II (H-2 d ) haplotype, we found that Foxp3 is early expressed in the CD3 + 4 8 25 +/44 (DN3/4) ...

As known for more than two decades, humans can learn to achieve self-control over their brain activity such as the polarity of slow cortical potential (SCP) shifts referred to as positivity or negativity. This learning process is supported by the visual feedback of the SCP in a time-locked trial structure. On the other hand, it has been repeatedly shown that humans are able to regulate the rand...

OBJECTIVE Infection by MTB or exposure to MTB constituents is associated with intense microbial stimulation of the immune system, through both antigenic and TLR components, and induction of a milieu that is rich in pro-inflammatory/anti-inflammatory cytokines. Here, we addressed the basis of induced regulatory T-cell (iT-reg) expansion in response to MTB stimulation, in the absence of prior T c...

BACKGROUND Pre- and early clinical studies on patients with autoimmune diseases suggested that induction of regulatory T(T(reg)) cells may contribute to the immunosuppressive effects of glucocorticoids (GCs). OBJECTIVE We readdressed the influence of GC therapy on T(reg) cells in immunocompetent human subjects and naïve mice. METHODS Mice were treated with increasing doses of intravenous de...

TITLE: iNOS expression in CD4+ T cells limits T-reg induction by repressing TGF-1: combined iNOS inhibition and T-reg depletion unmask endogenous anti-tumor immunity RUNNING TITLE: iNOS in CD4+ T cells limits T-reg induction by repressing TGF

Foxp3 is required for the generation and activity of CD4(+)CD25(+) regulatory T (T reg) cells, which are important controllers of autoimmunity, including type-1 diabetes. To determine where T reg cells affect the diabetogenic cascade, we crossed the Foxp3 scurfy mutation, which eliminates T reg cells, with the BDC2.5 T cell receptor (TCR) transgenic mouse line. In this model, the absence of T r...

For a closure space (P,φ) with φ(∅) = ∅, the closures of open subsets of P , called the regular closed subsets, form an ortholattice Reg(P,φ), extending the poset Clop(P,φ) of all clopen subsets. If (P,φ) is a finite convex geometry, then Reg(P, φ) is pseudocomplemented. The Dedekind-MacNeille completion of the poset of regions of any central hyperplane arrangement can be obtained in this way, ...

Peripheral immune tolerance requires a controlled balance between the maintenance of self-tolerance and the capacity to engage protective immune responses against pathogens. Dendritic cells (DCs) serve as sentinels of the immune system by sensing environmental and inflammatory signals, and play an essential role in the maintenance of immune tolerance. To achieve this, DC play a key role in dict...

Inflammatory bowel disease (IBD) is an idiopathic inflammatory disease of the intestine. CD4(+) T lymphocytes play an important role in both initiating and regulating intestinal inflammatory immune responses. CD4(+)CD25(+)CD45RB(low) regulatory T (T reg) cells are capable of preventing the development of colitis in a mouse model of IBD. The precise mechanism of T reg cell-mediated prevention of...