نتایج جستجو برای: regulatory networks
تعداد نتایج: 597741 فیلتر نتایج به سال:
Classification: Biological Sciences, Developmental Biology 1 2 Title: Divergence of gene regulatory network linkages during specification of ectoderm and 3 mesoderm in early development of sea urchins 4 5 Short Title: Divergence of GRNs in early echinoid embryos 6 7 Author Affiliations: 8 Eric M. Erkenbrack and Eric H. Davidson 9 10 Division of Biology and Biological Engineering, California Ins...
This contribution gives an initial report of a new project exploring the perspectives and limits of reversely engineering regulatory gene networks from gene expression data. The availability of such data is currently increasing dramatically due to the microarray technology. However, inferring the underlying network from expression data is difficult. We address the reverse engineering problem by...
The Genetic Analysis Workshop 15 (GAW15) Problem 1 contained baseline expression levels of 8793 genes in immortalized B cells from 194 individuals in 14 Centre d'Etude du Polymorphisme Humain (CEPH) Utah pedigrees. Previous analysis of the data showed linkage and association and evidence of substantial individual variations. In particular, correlation was examined on expression levels of 31 gen...
1 Univ Lyon, ENS de Lyon, Univ Claude Bernard, CNRS UMR 5239, INSERM U1210, Laboratory of Biology and Modelling of the Cell, 46 allée d’Italie Site Jacques Monod, F-69007 Lyon, France 2 Inria Team Dracula, Inria Center Grenoble Rhône-Alpes, France 3 Université de Lyon, Université Lyon 1, CNRS UMR 5208, Institut Camille Jordan 43 blvd du 11 novembre 1918, F-69622 Villeurbanne-Cedex, France 4 The...
Background
Gene operation and interaction occur in every organism. Gene network is commonly used to describe gene interaction issues due to its complicity. Simulation of gene networks operation is an essential problem of bioinformatics. System providing tools for creating, setting up and simulating gene networks is described. Broad simulation abilities along with high extensibility are system’s advantages...
Modelling frameworks for biological networks are used to reason on the models and their properties. One of the main problems with such modelling frameworks is to determine the dynamics of gene regulatory networks (GRN). Recently, it has been observed in in vivo experiments and in genomic and transcriptomic studies, that spatial information is useful to better understand both the mechanisms and ...
MOTIVATION Epistasis analysis is an essential tool of classical genetics for inferring the order of function of genes in a common pathway. Typically, it considers single and double mutant phenotypes and for a pair of genes observes whether a change in the first gene masks the effects of the mutation in the second gene. Despite the recent emergence of biotechnology techniques that can provide ge...
The efficacy of a newly created software package for predictive modeling of developmental gene regulatory networks (GRNs) has recently been demonstrated (Peter et al., 2012 ). The program GeNeTool computes spatial gene expression patterns based on GRN interactions and thereby allows the direct comparison of predicted and observed spatial expression patterns. GeNeTool also permits in silico expl...
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