In interphase HeLa cells, incubation with histamine or thapsigargin led to the rapid release of arachidonic acid. The release was absolutely dependent on Ca2+, consistent with the activation of an 85 kDa cytosolic phospholipase A2 (cPLA2). In metaphase-arrested HeLa cells, by contrast, the stimulation of arachidonate release by these agents was inhibited by more than 90%. The lack of arachidoni...

Since the last decade, polymer-drug conjugate (PDC) approach has emerged as one of most promising drug-delivery technologies owing to several benefits like circumventing premature drug release, offering controlled and targeted delivery, improving stability, safety, kinetics conjugated drugs, so forth. In recent years, PDC technology advanced with objective further enhance treatment outcomes by ...

It remains a great challenge to accurately deliver the therapeutic agents tumor lesions enhance antitumor efficacy and reduce side effects. Herein, an implantable polydopamine (PDA) nanoparticle-in-nanofiber device for local combination of photothermal therapy (PTT) chemotherapy against cancer is developed. This system can continuously release small-sized PDA nanoparticles with targeting superi...

in this study, attempts were made to evaluate the effect of various acrylic acid based carbopols on the release profile of a beta-adrenoreceptor blocking drug, propranolol hcl, from matrix-type tablets invitro. for this purpose, tablets containing 160 mg of propranolol hcl along with various amounts of carbopols 934 (c934), 971 (c971), 974 (c974) and pemulen (pem) were prepared using the wet gr...

The amine-carboxyboranes anti-inflammatory agents were shown to block TNF alpha release at 90 min. and IL-1 release at 5 hr. from macrophages. The agenst competed with L929 fibroblasts high affinity receptors for endogenous cytokines which regulate the inflammation process. Blocking the TNFalpha receptor at 90 min. by the agents from 10 to 50 muMu, resulted in lysosomal hydrolytic enzyme inhibi...

Background: Rhabdomyolysis is caused by the release of enzymes from skeletal muscles into the blood, which leads to systemic complications with diverse etiologies. This study evaluated the serum aminotransferases in patients with rhabdomyolysis following acute intoxication with either psychotropic drugs or other chemical agents. Methods: This study randomly recruited 140 patients suffering fro...

Electrospinning has been one of the most attractive methods fiber fabrication in last century. A lot studies have conducted, especially tissue engineering and drug delivery using electrospun fibers. Loading many different drugs bioactive agents on or within these fibers potentiates efficacy such systems; however, there are still no commercial products with this technology available market. Vari...

ATP can be released from a variety of cell types by mechanical stimulation; however, the mechanism for this release and the influence of pathology are not well understood. The present study examined intracellular signaling mechanisms involved in swelling-evoked (exposure to a hypotonic solution) release of ATP in urothelial cells from normal cats and cats diagnosed with interstitial cystitis (f...

Gastro retentive floating tablet of Simvastatin was prepared by direct compression technique using Methocel K4M as the rate controlling polymer. The hydrophilic cellulose derivative, Methocel K4M was evaluated for its gel forming and release controlling properties. Sodium bicarbonate and citric acid were incorporated as gas generating agents. The effects of soluble components (sodium bicarbonat...

Lipids are commonly used excipients in drug delivery for improving solubility of low soluble drugs, enhancing bioavailability through avoiding first pass metabolism nanoparticulate approach, modifying the release, binders, permeation enhancers, transfection agents etc. alone or combination polymers increasingly being hot melt extrusion (HME) technology preparation controlled release formulation...