BACKGROUND Natural gums are polymers widely used as excipients in drug formulation. Polymer extraction and formulation processing methods could significantly affect formulation characteristics. OBJECTIVES To evaluate different methods of gum extraction and the effect of different compression methods on the mechanical and release properties of tramadol hydrochloride matrix tablets incorporatin...

The purpose of the present work was to prepare buccal adhesive tablets of miconazole nitrate. The simplex centroid experimental design was used to arrive at optimum ratio of carbopol 934P, hydroxypropylmethylcellulose K4M and polyvinylpyrollidone, which will provide desired drug release and mucoadhesion. Swelling index, mucoadhesive strength and in vitro drug release of the prepared tablet was ...

Chitosan/ghatti gum polyelectrolyte complexes were synthesized using different proportions of chitosan (CH) and ghatti gum (GG). The optimum CH: GG ratio was 20:80, which produced highest product yield. Polyelectrolyte (PEC) samples were characterized by differential scanning calorimetry (DSC) and FT-IR spectroscopy. Matrix tablets using PEC as matrix and Diltiazem Hcl as a model drug were form...

The objective of the present study was to design an oral controlled drug delivery system for sparingly soluble diclofenac sodium (DCL) using guar gum as triple-layer matrix tablets. Matrix tablet granules containing 30% (D1), 40% (D2) or 50% (D3) of guar gum were prepared by the conventional wet granulation technique. Matrix tablets of diclofenac sodium were prepared by compressing three layers...