The purpose of the research was to formulate microspheres of acyclovir (ACV) using mucoadhesive polymers, sodium alginate and chitosan. Calcium chloride was used as the ionotropic gelling agent. Sodium alginate was crosslinked by calcium chloride leading to a slower release of the drug. Chitosan which is a cationic polymer interacted with sodium alginate, an anionic polymer, to form an interpol...

      Mucoadhesive polymers that bind to the gastric mucin or epithelial cell surface are useful in drug delivery for the purpose of increasing the intimacy and duration of contact of drug with the absorbing membrane. Several synthetic polymers are in use for this purpose. Since the biodegradability of the synthetic polymers are questionable, in this investigation, an oral mucoadhesive controll...

OBJECTIVE Adrenal insufficiency (AI) is a chronic condition associated with increased mortality and morbidity. The treatment of AI in the last years has been object of important changes due to the development of a dual-release preparation of hydrocortisone. It differs from previous therapeutic strategy as it contemplates a once-daily tablet that allows more closely mimicking the physiological c...

The objective of the present study was to prepare controlled release formulation of Moxifloxacin hydrochloride ocular nanoparticles. The nanoparticles were prepared by solvent displacement method using Eudragit RL 100 as a polymer. Different formulations were prepared by varying the ratios of drug and polymer and varying the ratios of organic and aqueous phase. The formulations were evaluated i...

Hydrogel Based Metronidazole Bioadhesive Tablet (HMBT) was prepared as a novel vaginal delivery system to achieve Controlled release of drug from the tablet for vaginal candidiasis. The highly swollen hydrogel were prepared by dissolving chitosan in acetic acid solution containing drug, followed by neutralisation with sodium hydroxide and characterized by SEM, DSC and FT-IR and evaluated for % ...

This research focused on preparing a ketoconazole-infused silk fibroin hydrogel to enhance patient compliance, leveraging the hydrogel's biocompatibility and biodegradability. The process used 50% (v/v) ethanol, propanol, or glycerol solution treated with 2% (w/v) at 37°C. use of quickened gelation process. structure was analyzed via SEM, UV-VIS spectrometry evaluate encapsulation efficiency ke...

The fiber damage during manufacture, use, and service of textiles leads to fragmented generation. All (natural, regenerated, synthetic polymer sources) release fragments. Several textile structural parameters have been studied in association with release; however, there is a paucity work on the effect different types yarn structures release. This study elucidates impact key (rudimentary element...

Hot-melt coating process (HMCP) was applied to develop a lipid based oral controlled release matrix system (tablet) to deliver highly aqueous soluble drugs using paracetamol as a model drug. Granules prepared from paracetamol and particular filler were coated with different levels of lipid and then compressed into tablets to get controlled/sustained delivery of the drug over an optimum period. ...

background microencapsulation is a useful method to prolong a drug release from dosage forms and to reduce its adverse effect (1) among various available methods. the microencapsulation of hydrophilic active ingredients requires the use of a polar dispersing phase such as a mineral oil. acetone/paraffin systems are conventionally used. objectives the current study aimed to investigate two diffe...

implantable contraceptive is likely to be a promising new option for fertility control, as we have entered the twenty-first century and the world’s population grows by one billion people in a single decade. the main objective of this study was to develop a subdermal implant for levonorgestrol (a synthetic progestin from 19-norandrostanes) using a high molecular weight biodegradable polymer , i....