A handicapped child is a handicapped family. I don't know who said it, but it is very, very true. I was eight years old when my sister, three years my senior, fell ill with osteomyelitis. It turned out to be an extremely long and very serious disease. She finally recovered but was unable to cope with the legacy of her illness, a physical handicap. Not all that catastrophic, had her previous per...

Some of the signaling molecules required for formation of long-term memories are involved primarily in adult brain function, but others participate in a variety of other biological processes. The Notch signaling pathway, which is important for cell fate specification and differentiation in various systems, is also active in the mature brain. Here, we review evidence from recent studies indicati...