Heritability is a central element in quantitative genetics. New molecular markers to assess genetic variance and heritability are continually under development. The availability of molecular single nucleotide polymorphism (SNP) markers can be applied for estimation of variance components and heritability on population, where relationship information is unknown. In this study, we evaluated the c...

Linear mixed models (LMMs) are among the most commonly used tools for genetic association studies. However, the standard method for estimating variance components in LMMs-the restricted maximum likelihood estimation method (REML)-suffers from several important drawbacks: REML requires individual-level genotypes and phenotypes from all samples in the study, is computationally slow, and produces ...

BACKGROUND The Hovawart is a working and companion dog breed of German origin. A few hundred Hovawart dogs are registered annually in Finland. The most common disease with a proposed genetic background in Hovawarts is hypothyroidism. The disease is usually caused by lymphocytic thyroiditis, an autoimmune disorder which destroys the thyroid gland. Hypothyroidism can be treated medically with hor...

The ranking of hybrids via genotypic values stands out due to its maximum selective accuracy in relation ordering based on phenotypic values, which incorporate environmental effects, causing changes the final classification. aim this study was pre-select cloned pineapple for higher total soluble solids (TSS) and larger fruit mass without crown (FMWC). It evaluated with 364 propagated vegetative...

Knowledge of genetic parameters and variances is an essential pre-requisite for tasks such as the design of selection programmes or prediction of breeding values. Reliable estimation of these quantities is thus paramount. There is a growing trend to consider more and more complex phenotypes, necessitating multivariate analyses comprising numerous traits. Problems inherent in such analyses, aris...

ABSTRACT: The genotype × environment (G×E) interaction plays an essential role in phenotypic expression and can lead to difficulties genetic selection. Thus, the present study aimed estimate parameters compare different selection strategies context of mixed models for soybean breeding. For this, data referring evaluation 30 genotypes 10 environments, regarding grain yield trait, were used. vari...

BACKGROUND Postprandial hyperlipidaemia is known to be a high-risk factor for atherosclerotic disease because of rapid and lasting accumulations of triglyceride-rich lipoproteins and remnants. The Niemann-Pick C1-Like 1 (NPC1L1) protein acts as an intestinal cholesterol transporter and ezetimibe, which inhibits NPC1L1, has been used in patients with hypercholesterolaemia. We investigated effect...

Lethal recessive genes that cause early embryo loss are difficult to detect. Nonreturn rate at 70 d after first insemination (NR) was evaluated as a trait of the embryo using 1,739,055 first-service records from 1,251 Holstein bulls represented as both service sires and sires of cows. Effects modeled included herd-year-season, parity of cow, sire of cow, service bull, interaction of service bul...