nuclear medicine imaging is routinely used for evaluation of perfusion and function of the transplanted kidneys. at present, the radiopharmaceutical of choice for this study in our center is tc 99m-ec. complications of the kidney graft are demonstrable in the early and delayed images. one of these complications is vesicoureteral reflux to the graft or to the native kidneys. we present a 27 year...

BACKGROUND Patients with chronic severe anaemia often retain salt and water. Fluid retention in these patients is not caused by heart failure and the exact mechanisms remain unclear. This study was designed to examine some of the possible mechanisms. METHODS AND RESULTS Haemodynamic variables, body fluid compartments, renal function, and plasma hormones were measured in four patients with oed...

BACKGROUND Although renal denervation significantly reduces blood pressure in patients with resistant hypertension, the role of the renal nerve in hypertension with metabolic syndrome is unknown. We investigated the impact of long-term renal denervation on SHR/NDmcr-cp(+/+) (SHRcp) rats, a useful rat model of metabolic syndrome, to determine the role of the renal nerve in hypertension with meta...

S INCE the work of Starr [7] who concluded that the increase in venous pressure observed in congestive heart failure is due to an increased plasma volume, the “forward” theory of heart failure has been the subject of much research attempting to describe the precise mechanisms by which the extracellular volume is expanded during cardiac decompensation. Warren and Stead [Z] emphasized the diminis...

The diagnosis of uraemia is often considered synonymous with a hopeless prognosis, or, at best, a condition from which a patient may recover but on which treatment has no specific effect. This paper attempts to set out a rational system of treatment for uraemia. The clinical picture, aetiology of the renal failure, diagnosis and prognosis are briefly considered before treatment is discussed. Fi...

Thirty patients suffering from chronic kidney disease were examined for urinary, fecal and total plasma porphyrins. Twenty patients had nitrogen retention whereas the remaining ten patients displayed normal values. Urinary coproporphyrin excretion and total plasma porphyrin levels were comparatively less pronounced in patients with nitrogen retention. Such changes in porphyrin metabolism could ...

24 The ‘Guytonian paradigm’ places the direct effect of arterial pressure, on renal excretion of salt and 25 water, at the center of long-term control of blood pressure and thus the pathogenesis of 26 hypertension. It originated in the sixties and remains influential within the field of hypertension 27 research. However, the concept of one central long-term feedback loop, through which arterial...

The "Guytonian paradigm" places the direct effect of arterial pressure, on renal excretion of salt and water, at the center of long-term control of blood pressure, and thus the pathogenesis of hypertension. It originated in the sixties and remains influential within the field of hypertension research. However, the concept of one central long-term feedback loop, through which arterial pressure i...