نتایج جستجو برای: replication genes 16 and 52
تعداد نتایج: 16939922 فیلتر نتایج به سال:
................................................................................................................................................................................. 36 Introduction ......................................................................................................................................................................... 37 Results .........................
Herpesviruses are helper viruses for productive adeno-associated virus (AAV) replication. To analyze the herpes simplex virus type 1 (HSV-1) functions mediating helper activity, we coinfected HeLa cells with AAV type 2 (AAV-2) and different HSV-1 mutants defective in individual HSV replication genes. AAV replication was fully accomplished in the absence of HSV DNA replication and thus did not r...
Mutations in genes involved in DNA replication, such as flap endonuclease 1 (FEN1), can cause single-stranded DNA breaks (SSBs) and subsequent collapse of DNA replication forks leading to DNA replication stresses. Persistent replication stresses normally induce p53-mediated senescence or apoptosis to prevent tumour progression. It is unclear how some mutant cells can overcome persistent replica...
The effects of 52 weeks of soccer or resistance training were investigated in untrained elderly men. The subjects aged 68.1±2.1 yrs were randomised into a soccer (SG; n = 9), a resistance (RG; n = 9) and a control group (CG; n = 8). The subjects in SG and RG, respectively, trained 1.7±0.3 and 1.8±0.3 times weekly on average during the intervention period. Muscle function and body composition we...
Background The SAPHYR study ( NCT03600818 ) in patients with polymyalgia rheumatica (PMR) who were resistant to glucocorticoid (GC) taper met the primary endpoint a significantly higher proportion of sarilumab arm versus comparator achieving sustained remission from weeks 12 52 (28.3% vs 10.3%; P=0.0193) [1] . Sarilumab, when administered rheumatoid arthritis at dose 200 mg subcutaneously, achi...
Background: P. gingivalis is the prime aetiological bacteria of initiation and progression of periodontal disease. It is also the risk factor of many system diseases, such as cardiovascular disease, diabetes and pulmonary infection. This study is aiming to demonstrate the effects of stimulated microgravity on p. gingivalis ATCC33277. Methods: We performed the rotary cell culture system (RCCS) t...
esophageal squamous cell carcinoma (escc) is a deadly cancer with poor prognosis. in this regard, early diagnosis is of vital importance to cure the tumor in its early stages. novel cancer diagnostic and therapeutic approaches have been recently introduced based on micrornas (mirnas). also, accurate normalization using appropriate reference genes is a critical step in mirna expression studies. ...
Cancer, as one of the most serious public health problems, is the second-leading cause of death in the world after cardiovascular disease. The number of patients and the resulting mortality are increasing worldwide; therefore, early diagnosis, prevention, and effective treatment of cancer are very important. Current treatments such as chemotherapy and radiation therapy are often non-selective a...
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