BACKGROUND Venous thrombosis is common in nephrotic syndrome, but portal vein thrombosis has a relatively low incidence in patients with nephrotic syndrome. We describe here a case of an 18-year old male student with newly diagnosed nephrotic syndrome that was complicated with portal, splenic and superior mesenteric vein thrombosis. CONCLUSION In the presence of newly diagnosed nephrotic synd...

Introduction AA amyloidosis may develop as a consequence of chronic inflammatory conditions including inherited periodic fever syndromes. Mevalonate-kinase (MVK) deficiency (MKD) appears to be the least frequent underlying condition after FMF, TRAPS and CAPS. Moreover, amyloidosis rarely manifests during childhood. We report a case of a small child in whom renal biopsy performed because of the ...

BACKGROUND Klippel-Trenaunay-Weber syndrome is a rare syndrome; unfortunately, very few studies of the connection between hypersplenism, nephrotic syndrome, and Klippel-Trenaunay-Weber syndrome have been published. CASE PRESENTATION We report the case of a 40-year-old white man with a typical clinical presentation of Klippel-Trenaunay-Weber syndrome, including "port-wine stains," varicose vei...

Hospital Physician October 2007 25 T he nephrotic syndrome is a constellation of renal and extrarenal manifestations that can be caused by a multitude of systemic diseases as well as by primary insults to the kidney. The prevalence of the syndrome depends largely on the underlying causes, which vary significantly by age of onset. The nephrotic syndrome is classically characterized by 6 main abn...

*Corresponding Author: Ahmadali Nikibakhsh MD, Associated professor of pediatric Nephrology Mailing Address: Nephrology and Transplantation Research Center, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran Tel: +98 151 2233011-15 Fax: +98 151 2234506 Email: [email protected] The efficacy of rituximab in treatment of childhood steroid resistant and steroid dependent nephrot...

Hyperlipidemia is a common feature of the nephrotic syndrome. Hyperlipidemia so commonly complicates with heavy proteinuria that it has come to be regarded as an integral features of nephrotic syndrome lipid abnormalities in patients with the nephrotic syndrome have been recognized. 2 Lipoprotein abnormalities of the nephrotic syndrome are assumed to be related to the presence of proteinuria an...

UNLABELLED Tregs infusion reverts proteinuria and reduces renal lesions in most animal models of nephrotic syndrome (i.e. Buffalo/Mna, Adriamycin, Promycin, LPS). IL2 up-regulates Tregs and may be an alternative to cell-therapy in this setting. To evaluate a potential role of IL2 as Tregs inducer and proteinuria lowering agent in human nephrotic syndrome we treated 5 nephrotic patients with 6 m...

The present study aimed to screen for urinary biomarkers of steroid-resistant nephrotic syndrome (SRNS) in children. These biomarkers were divided into three groups, the control, the steroid-sensitive nephrotic syndrome (SSNS) and the SRNS groups, which were composed of 45, 32 and 9 children, respectively. Urine samples were obtained and analyzed using Au-chips. Compared with the control group,...

BACKGROUND AND OBJECTIVES In steroid-resistant nephrotic syndrome (SRNS), >21 single-gene causes are known. However, mutation analysis of all known SRNS genes is time and cost intensive. This report describes a new high-throughput method of mutation analysis using a PCR-based microfluidic technology that allows rapid simultaneous mutation analysis of 21 single-gene causes of SRNS in a large num...

Focal segmental glomerulosclerosis (FSGS) is a common cause of steroid-resistant nephrotic syndrome in children and adults. Although FSGS is considered a podocyte disease, the aetiology is diverse. In recent years, many inheritable genetic forms of FSGS have been described, caused by mutations in proteins that are important for podocyte function. In the present commentary, we review these genet...