Purpose: Magnetic resonance spectroscopic imaging (MRSI) provides complementary information to conventional magnetic resonance imaging. Acquiring high resolution MRSI is time consuming and requires complex reconstruction techniques. Methods: In this paper, a patch-based super-resolution method is presented to increase the spatial resolution of metabolite maps computed from MRSI. The proposed me...

Fresnel transform implementation methods using numerical preprocessing techniques are investigated in this paper. First, it is shown that up-sampling dramatically reduces the minimum reconstruction distance requirements and allows maximal signal recovery by eliminating aliasing artifacts which typically occur at distances much less than the Rayleigh range of the object. Second, zero-padding is ...

We analyze a planar lens with negative index of refraction to develop analytical expressions describing EM evanescent and propagating waves. Resolution, field magnitude, and field intensity of the superlens is identical for equal absorption and gain parameters. Subwavelength resolution is achieved by the Planar NIM lens in the near-field regime due to amplification and recovery of evanescent fi...

Coherent diffractive imaging using a coherent X-ray source promises to be a useful microscopic method for imaging noncrystalline objects at high spatial resolution. In this article a simple method to estimate the coherently scattered signal as a function of resolution is presented, and it is shown that the required X-ray flux or dose scales as the inverse third power of resolution for a specime...

SPECT imaging suffers from low spatial resolution and statistical noise. Consequently, the contrast of small structures is reduced, visual detection of defects is limited and exact quantification is difficult. To improve the contrast, it is possible to incorporate a blurring model into the iterative reconstruction process such as OSEM3D. This approach is well known to be effective, but time con...

Immune regulation of autoimmune disease can function at two sites: at the secondary lymphoid organs or in the target organ itself. In this study, we investigated the natural resolution of autoimmune pathology within the CNS using murine experimental autoimmune encephalomyelitis (EAE). Recovery correlates with the accumulation of IL-10-producing CD4+CD25+ T cells within the CNS. These CD4+CD25+ ...

OBJECTIVE To examine the time course for the onset of, and recovery from, acute hypoglycemia in healthy subjects. RESEARCH DESIGN AND METHODS Eight healthy male volunteers were studied on 2 occasions in random order using a hyperinsulinemic (1.5 mU x kg(-1) x min(-1)) glucose clamp technique. During control studies, euglycemia (5.01 +/- 0.02 mmol/l) was maintained for 225 +/- 3 min. On the ot...

We propose a convex variational framework to compute high resolution images from a low resolution video. The image formation process is analyzed to provide to a well designed model for warping, blurring, downsampling and regularization. We provide a comprehensive investigation of the single model components. The super-resolution problem is modeled as a minimization problem in an unified convex ...

The rate at which photoreceptors recover from excitation is thought to be critical for setting the temporal resolution of vision. Indeed, mutations in RGS9 (regulator of G-protein signaling 9) and R9AP (RGS9 anchor protein) proteins mediating rapid photoresponse recovery impair patients' ability to see moving objects. In this study, we analyzed temporal properties of retinal sensitivity and spa...

Spectral Doppler ultrasound imaging allows visualizing blood flow by estimating its velocity distribution over time. Duplex ultrasound is a modality in which an ultrasound system is used for displaying simultaneously both B-mode images and spectral Doppler data. In B-mode imaging short wide-band pulses are used to achieve sufficient spatial resolution in the images. In contrast, for Doppler ima...