Oligoclonal bands were identified in electropherograms of cerebrospinal fluid, and the "gamma-protein index" was concurrently calculated from the same strip. For the index, an upper limit of normal of 0.66 was established. We compared results with the clinical diagnosis in 69 patients with multiple sclerosis and 48 control patients with other diseases. Sensitivity, specificity, and positive pre...

The anti-malarial activity of the anti-cancer drug methotrexate against chloroquine-sensitive T9-96 and the multidrug-resistant K1 strains of Plasmodium falciparum was assessed in vitro. Mean IC50 values of 0.32 +/- 0.05 nM and 48.02 +/- 4.40 nM were obtained for T9-96 and K1, respectively, indicating methotrexate's high potency against both sensitive and resistant P. falciparum strains in vitr...

Purpose The aim of this audit was to assess the overall experience and patient convenience of vaginal progesterone tablets (Lutigest®, marketed as Endometrin® in the USA) used for luteal phase support (LPS) during in vitro fertilization (IVF) treatment. Patients and methods This questionnaire-based audit included responses from 100 patients undergoing IVF treatment at six IVF clinics in the U...

OBJECTIVES The aim of this study was to compare the diagnostic performance of multidetector computed tomography (MDCT) with prospective electrocardiogram (ECG) triggering versus retrospective ECG triggering. BACKGROUND MDCT allows the noninvasive visualization of the coronary arteries. However, radiation exposure is a reason for concern. METHODS One hundred eighty consecutive patients sched...

elicitation with middle-viscous chitosan (30 mg/50 ml) significantly stimulated silymarin synthesis in silybum marianum hairy root cultures. the root cultures established by infection with agrobacterium rhizogenes ar15834 showed a potential for production of silymarin. elicitation with medium molecular weight of chitosan (0, 5, 10, 20, and 30 mg/50 ml) was used in order to improve silymarin pro...

The 96 hrs LC50 values for malathion and glyphosate was determined to be 9.1 ppm and 5.5 ppb, respectively on the fairy shrimp, Streptocephalus dichotomus preadults. The 1/5 of 96 hrs LC50 of malathion (2.0 ppm) and glyphosate (1.1 ppb) respectively was chosen. The sub lethal toxic effect of each of these pesticides on the acetylcholinesterase activity (AchE) of S. dichotomus was assayed on day...

1. The effect of chronic treatment with ethanol (14% v:v in drinking water) on the physiological endpoint core temperature which is partially regulated by a muscarinic mechanism was measured in adult male rats (n = 8). 2. One and two weeks of treatment were associated with enhancement of the hypothermic response to oxotremorine, 0.25 mg/kg ip (p = 0.0005 and p = 0.0001, respectively). 3. The sa...

Mitomycin C (MMC) generates free radicals when metabolized. We investigated the effect of melatonin against MMC-induced genotoxicity in polychromatic erythrocytes and MMC-induced lipid peroxidation in brain and liver homogenates. Rats (N = 36) were classified into 4 groups: control, melatonin, MMC, and MMC + melatonin. Melatonin and MMC doses of 10 mg/kg and 2 mg/kg, respectively, were injected...