BACKGROUND The spontaneous breathing pattern and its relationship to compliance, resistance, and work of breathing (WOB) has not been examined in patients with acute respiratory distress syndrome (ARDS) or acute lung injury (ALI). Clinically, the ratio of respiratory frequency to tidal volume (f/VT) during spontaneous breathing may reflect adaptation to altered compliance, resistance, and incre...

In this paper, a new method is proposed for the speed control of a three-phase current forced synchronous machine drive. This metohd is based on the use of an approximate constant commutation safety margin angle in the output thyristor bridge of the drive system as well as on the compenastion of stator magnetization reaction. The commutation process in the output converter of the machine driv...

In this paper, using a personal computer (PC), the practical implementation of scalar and vector control methods on a three–phase rotor surface- type permanent magnet synchronous machine drive is discussed. Based on the machine dynamic equations and the above control strategies, two block diagrams are presented first for closed-loop speed controlling of the machine drive/system. Then, the desig...

in this paper, the finite element analysis of stability problem of vehicle composite drive shafts subjected to torsional loading is studied. first, using the minimum total potential energy principle, the governing equations are derived and then they are solved by finite element method. the initial geometrical imperfection which is usually in the form of radial displacement, is taken into consid...

Inspiratory neurons of the preBötzinger complex (preBötC) form local excitatory networks and display 10-30 mV transient depolarizations, dubbed inspiratory drive potentials, with superimposed spiking. AMPA receptors are critical for rhythmogenesis under normal conditions in vitro but whether other postsynaptic mechanisms contribute to drive potential generation remains unknown. We examined syna...

Electrical or natural stimulation of the vestibular system results in changes in blood pressure and respiratory motor output. An increase in excitatory drive on the sympathetic nervous system occurs during nose-up vestibular stimulation in cats; this response is appropriate to offset orthostatic hypotension that could result from nose-up body rotations during movements such as vertical climbing...

Primary culture models of single adult skeletal muscle fibers dissociated from locomotor muscles adhered to glass coverslips are routine and allow monitoring of functional processes in living cultured fibers. To date, such isolated fiber cultures have not been established for respiratory muscles, despite the fact that dysfunction of core respiratory muscles leading to respiratory arrest is the ...

The effects of nitric oxide (NO) on respiratory-related neural activity were investigated using the isolated brainstem preparation from bullfrogs (Rana catesbeiana). Addition of the NO donor, sodium nitroprusside (SNP), or the amino acid precursor for NO synthesis, L-arginine (L-Arg), produced significant increases in respiratory-related burst frequency. Inhibition of nitric oxide synthase (NOS...

Building largely on the results of previous studies of motor control in respiration the role of proprioceptive control of respiratory movements is discussed with particular reference to the significance of the following points: (i) The co-activation of fusimotor and alpha motoneurons in load compensation and in the control of velocity and force of the respiratory movements. (ii) The convergence...

Hyperventilation is a common feature of disordered breathing. Apnea ensues if CO2 drive is sufficiently reduced. We tested the hypothesis that medullary raphé, ventral respiratory column (VRC), and pontine neurons have functional connectivity and persistent or evoked activities appropriate for roles in the suppression of drive and rhythm during hyperventilation and apnea. Phrenic nerve activity...