Objective(s): Pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. Researchers have intended to reformulate drugs so that they may be more safely used in human body. The more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. The aim of t...

Mesoporous Materials In article number 2208316, Xiaohui Ju and co-workers report the design of free-blockage reactive oxygen species (ROS)-responsive mesoporous silica nanoparticles (MSNs) as potential drug delivery systems. Methyl sulfide units are functionalized onto MSNs through co-condensation or grafting pathways. an ROS-rich environment, nanocarriers undergo structure polarity changes rel...

A series of multi-functional hydrogel systems have been designed and synthesized for potential brain implantation to realize controlled and sustained release of Nerve Growth Factor (NGF) for the treatment of Alzheimer’s disease (AD). The systems are three-dimensional crosslinked copolymers composed of a thermo-responsive unit, a hydrolytically degradable and hydrophobic unit, and an enzymatical...

Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being extensively studied due to their excellent delivery performance. Compared with other vehicles, CPPs hold promise delivering different types of drugs. Here, we review the development process and summarize composition classification CPP-based systems, cellular uptake mechanisms, influencing factors, biological bar...

Introduction Stimuli-responsive gels that exhibit swelling/shrinking changes in response to environmental changes such as pH and temperature have many future opportunities as suitable materials for mimicking biomolecules and designing smart systems in the biochemical and biomedical fields [1]. For example, self-regulated drug delivery can be achieved by loading a drug within pHand temperature-r...

Mesoporous silica nanoparticles (MSNs) have garnered a great deal of attention as potential carriers for therapeutic payloads. Here, we report a pH-responsive drug-carrier based on chondroitin sulfate functionalized mesostructured silica nanoparticles (NMChS-MSNs) ie, the amidation between NMChS macromer and amino group functionalized MSNs. The prepared nanoparticles were characterized using dy...

To explore the potential role of polymers in the development of drug-delivery systems, this study investigated the use of β-cyclodextrin (β-CD), carboxymethyl cellulose (CMC), acrylic acid (AA) and N' N'-methylenebis-acrylamide (MBA) in the synthesis of hydrogels for controlled drug delivery of acyclovir (ACV). Different proportions of β-CD, CMC, AA and MBA were blended with each other to fabri...

Nanotechnology in Therapeutics: Current Technology and Applications, Edited by Nicholas A. Peppas, J. Zach Hilt and J. Brock Thomas (Horizon Bioscience, 2007) contains seventeen chapters written by leading specialists in the field of polymeric materials for drug delivery and holds wealth of background as well as state of the art material divided into four sections: "Intelligent Therapeutics and...

Objective(s): Researchers have intended to reformulate drugs so that they may be more safely used in human body. Polymer science and nanotechnology have great roles in this field. The aim of this paper is to introduce an efficient drug delivery vehicle which can perform both targeted and controlled antibiotic release using magnetic nanoparticles grafted pH-responsive polymer.<s...