BACKGROUND To report a case of severe vitamin B(12) deficiency anemia presenting with white centered retinal hemorrhages. METHODS Interventional case report. RESULTS A 40-year-old man, general practitioner himself, presented with a 1-day history of diminished left visual acuity and a drop-shaped central scotoma. The corrected visual acuities were 20/20, OD and 20/100, OS. Ophthalmic examina...

Introduction: Pancytopenia is condition in which there is reduction of all the 3 peripheral blood lineage and must be suspected on clinical grounds when a patient presents with unexplained pallor. Careful examination of a blood film is important if reason for the pancytopenia is not apparent from the clinical history. If this does not reveal the cause, bone marrow aspiration and trephine may be...

OBJECTIVE The objective of this study was to determine the frequency of common causes leading to Pancytopenia in patients presenting to tertiary care hospital at Karachi. METHODS A total of 62 patients with the diagnosis of Pancytopenia of more than one week duration were enrolled in the study. All patients underwent a detailed medical history and full physical examination followed by blood s...

It was confirmed by fecal excretion test and Schilling's urinary excretion test using vitamin B@12 labelled with @60Co (@60Co-B@12) that the intestinal absorption of vitamin B@12 was markedly disturbed in patients with pernicious anemia. When @60Co-B@12 was given by mouth together with hog intrinsic factor in patients with pernicious anemia, the intestinal absorption of @60Co-B@12 was restored ...