PURPOSE To present a new retinal layer segmentation technique for evaluation of nerve fiber hyperplasia in patients with autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). METHODS Five patients with a molecular diagnosis of ARSACS and five age- and sex-matched healthy controls underwent a full ophthalmologic examination, which included a new technique to segment the retinal l...

Purpose To examine the neuronal structural integrity of cornea and retina as markers for neuronal degeneration in nonproliferative diabetic retinopathy (NPDR). Methods Participants were recruited from the broader Brisbane community, Queensland, Australia. Two hundred forty-one participants (187 with diabetes and 54 nondiabetic controls) were examined. Diabetic retinopathy (DR) was graded acco...

BACKGROUND The purpose of this study was to determine the value of spectral domain optical coherence tomography (SD-OCT) in assessing patients with diffuse unilateral subacute neuroretinitis (DUSN). METHODS This was an observational case series with clinical imaging correlation performed at the Retina and Vitreous Institute of Londrina and State University of Londrina, Paraná, Brazil. The ser...

OBJECTIVE The aim of this article is to characterize pathomorphologic changes within particular layers of fluorescein angiographically 'ischemic' compared to 'nonischemic' retina in patients with diabetic retinopathy. METHODS Cross-sectional images of ischemic retinal areas were obtained using Heidelberg Spectralis optical coherence tomography (OCT). Presumed retinal ischemia was defined as f...

BACKGROUND Diabetic retinopathy is a microvascular neurodegenerative disorder in diabetic patients. Peripapillary retinal nerve fiber layer changes have been described in patients with preclinical diabetic retinopathy, but study results have been inconsistent. OBJECTIVE To assess changes in peripapillary retinal nerve fiber layer thickness in diabetic patients with preclinical diabetic retino...

PURPOSE To evaluate changes in retinal nerve fiber layer (RNFL) thickness after laser in situ keratomileusis (LASIK) using a scanning laser polarimeter with fixed corneal compensation (GDx) and the retinal thickness analyzer (RTA). METHODS Thirty-eight eyes of 19 healthy subjects (10 female and 9 male; mean age 37.0-/+8.8 years) underwent GDx and RTA measurements before and after LASIK. All s...

PURPOSE To report an image segmentation algorithm that was developed to provide quantitative thickness measurement of six retinal layers in optical coherence tomography (OCT) images. DESIGN Prospective cross-sectional study. METHODS Imaging was performed with time- and spectral-domain OCT instruments in 15 and 10 normal healthy subjects, respectively. A dedicated software algorithm was deve...