The present work reports the effect of confinement, and temperature therein, on the conformational fluctuation dynamics of domain-I of human serum albumin (HSA) by fluorescence correlation spectroscopy (FCS). The water-pool of a sodium bis(2-ethylhexyl)sulfosuccinate (AOT) reverse micelle has been used as the confined environment. It was observed that the conformational fluctuation time is abou...

In contrast to diffraction methods, which deal with the coherence lengths ofabout 150 –200 nm, only very few unit cells of a definite structure are required forRaman scattering identification. This allows the micro-structural analysis ofamorphous materials. However, until the vibrational properties of glasses are betterunderstood in terms of their structure and bonding, vibratio...

Bio-based surfactants have attracted increasing attention due to their renewable resources and excellent surface properties. In this study, a novel bio-based sulfonic zwitterionic surfactant (BSZS) derived from transgenic soybean oil was prepared using a simple reaction route with two steps of the amidation and quaterisation. The bio-based sulfonic zwitterionic surfactant showed a critical mice...

Amphotericin B (AmB) and Nystatin (Nys) are the drugs of choice for treatment of systemic and superficial mycotic infections, respectively, with their full clinical potential unrealized due to the lack of high therapeutic index formulations for their solubilized delivery. In the present study, using a coarse-grained (CG) molecular dynamics (MD) simulation approach, we investigated the interacti...

In an aqueous medium, both pure and mixed surfactants form micelles after reaching a concentration called the critical micellar concentration (CMC), whose determination has considerable practical importance normally to understand the self-organizing behaviors of surfactants in exact and detailed ways. Many studies have been devoted to the elucidation of micellar structures under different condi...

Chemotherapy for cancer treatment has been demonstrated to cause some side effects on healthy tissues and multidrug resistance of the tumor cells, which greatly limits therapeutic efficacy. To address these limitations and achieve better therapeutic efficacy, combination therapy based on nanoparticle platforms provides a promising approach through delivering different agents simultaneously to t...

PURPOSE The failure of cancer treatments is partly due to the enrichment of cancer stem-like cells (CSLCs) that are resistant to conventional chemotherapy. A novel micelle formulation of oxaliplatin (OXA) encapsulated in chitosan vesicle was developed. The authors postulate that micelle encapsulation of OXA would eliminate both CSLCs and bulk cancer cells in colorectal cancer (CRC). EXPERIMEN...

Micelleplexes are a class of nucleic acid carriers that have gained acceptance due to their size, stability, and ability to synergistically carry small molecules. MicroRNAs (miRNAs) are small non-coding RNA gene regulator that is consists of 19-22 nucleotides. Altered expression of miRNAs plays an important role in many human diseases. Using a model 22-nucleotide miRNA sequence, we investigated...

A filament stretching extensional rheometer and capillary breakup extensional rheometer are used to measure the extensional rheology of a series of wormlike micelle solutions experiencing a uniaxial elongational flow. The experiments are performed using a series of wormlike micelle solutions of both cetylpyridinium chloride and sodium salicylate NaSal in an aqueous sodium chloride solution and ...

mPEG (monomethoxy poly(ethylene glycol))-maleic rosin copolymer was successfully prepared. The surface properties of the copolymer were investigated by surface tension and resonance scattering techniques. The critical micelle concentration (CMC) was obtained. The adsorption behaviors and the conformational changes of the surfactant molecules at the air-water interface were described. The adsorp...