Despite the tremendous success of cisplatin and other platinum-based anticancer drugs, severe toxicity and resistance to tumors limit their applications. It is believed that the coordination of the metal to DNA bases causes the ruptures of the cancer as well as normal cells. A search for anticancer drugs with different modes of action resulted in the synthesis of variety of novel compounds. Rec...

accelerated deactivation of co/al2o3 catalysts in fischer-tropsch synthesis and the effect of re and ru as the catalytic promoters are reported. 15wt% co/al2o3 catalyst and 1wt% ru and 1.4wt% re  promoted cobalt catalysts have been formulated and extensively characterized. the deactivation of the unpromoted cobalt catalyst and those promoted with re and ru were studied by accelerated method at ...

Herein, we present a full account of our efforts to couple the northern and the southern building blocks, the synthesis of which were described in the preceding paper, along with the modifications required to ultimately lead to a successful synthesis of laulimalide. Key highlights include an exceptionally efficient and atom-economical intramolecular ruthenium-catalyzed alkene-alkyne coupling to...