Rho family small GTPases (Rho, Rac, and Cdc42) play an important role in cell motility, adhesion, and cell division by signaling reorganization of the actin cytoskeleton. Here, we report an isoactin-specific, Rho GTPase-dependent signaling cascade in cells simultaneously expressing smooth muscle and nonmuscle actin isoforms. We transfected primary cultures of microvascular pericytes, cells rela...

Rho-kinase has been identified as one of the effectors of the small GTP-binding protein Rho. Accumulating evidence has demonstrated that Rho/Rho-kinase pathway plays an important role in various cellular functions, not only in vascular smooth muscle cell (VSMC) contraction but also in actin cytoskeleton organization, cell adhesion and motility, cytokinesis, and gene expressions, all of which ma...

A positive correlation between human population density and species richness has been recorded across the tropics. Here I investigate whether this correlation holds true for Europe. Analyses reveal a positive correlation between human population density and plant (rho = 0.505), mammal (rho = 0.471) and reptile and amphibian (rho = 0.556) species richness. The results are largely concordant with...

Deregulation of Rho GTPase expression and activity levels is found in a number of cancers, including breast cancers. Aberrant Rho GTPase signaling promotes tumorigenic behaviors in a cell-autonomous manner. The development of conditional knockout and overexpression mouse models of Rho GTPases and their regulators has allowed for investigation of the impact of aberrant Rho signaling in the conte...

Mature adipocytes and myocytes are derived from a common mesenchymal precursor. While IGF-1 promotes the differentiation of both cell types, the signaling pathways that specify the distinct cell fates are largely unknown. Here, we show that the Rho GTPase and its regulator, p190-B RhoGAP, are components of a critical switch in the adipogenesis-myogenesis "decision." Cells derived from embryos l...

In symptomatic subjects, the reliability of tests for shoulder joint range of motion has yet to be determined. For this reason, inter-rater and intra-rater agreement trials were undertaken to ascertain the reliability of visual estimation, goniometry, still photography, "stand and reach" and hand behind back reach for six different shoulder movements. Intra-class correlation coefficients (Rho) ...

Amaç: Koronavirüs hastalığı-2019 [coronavirus disease-2019 (COVID-19)] enfeksiyonu, yayılan damlacıkların solunması ve temas yoluyla bulaşan, semptomları ölüm oranları ile tüm dünyada korku endişeye neden olan bir hastalıktır. Fiziksel nedeniyle enfeksiyon riski yüksek futbolcular da bu durumdan etkilenmektedir. Bu çalışmanın amacı, COVID-19 korkusunun profesyonel futbolcularda uyku kalitesi, m...

The properties of the light vector meson states around 2.0 GeV have been poorly understood for a long time, which has become barrier to expansion higher spectrum. Recently, BESIII collaboration released measurements ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}\ensuremath{\omega}{\ensuremath{\pi}}^{0}$ and ${e}^{+}{e}^{\ensuremath{-}}\ensuremath{\rightarrow}\ensuremath{\rho}{\ensuremath{...