Given a finite generating set $T=\{g_0,\dots, g_n\}$ of group $G$, and representation $\rho$ $G$ on Hilbert space $V$, we investigate how the geometry $D(T,\rho)=\{ [x_0 : \dots x_n] \in\mathbb C\mathbb P^n \mid \sum x_i\rho(g_i) \text{ not invertible} \}$ reflects properties $\rho$. When $V$ is finite-dimensional this an algebraic hypersurface in $\mathbb P^n$. In special case $T=G$ $\rho=$ le...

Rho GTPases are members of the Ras superfamily and are involved in signal transduction pathways, including maintenance of cell morphology and motility, cell cycle progression, and transcription activation. We report the molecular identification in trypanosomatids (Trypanosoma cruzi) of the first member of the Rho family. The cloned Rho protein, TcRho1, shares approximately 40% homology with oth...

ADMA (asymmetric dimethylarginine) is a cardiovascular risk factor and an endogenous inhibitor of NOS (nitric oxide synthase). ADMA is metabolized by DDAHs (dimethylarginine dimethylaminohydrolases). ADMA levels are increased in cardiovascular disorders associated with abnormal angiogenesis but the mechanisms are poorly understood. Recent studies show that altering ADMA metabolism in vivo and i...

Nagaoka, Tetsutaro, Yoshiteru Morio, Nina Casanova, Natalie Bauer, Sarah Gebb, Ivan McMurtry, and Masahiko Oka. Rho/ Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 287: L665–L672, 2004. First published September 5, 2003; 10.1152/ ajplung.00050.2003.—Recent evidence suggests that Rho/Rho kinase signaling plays...

We study the spin-exotic $J^{PC} = 1^{-+}$ amplitude in single-diffractive dissociation of 190 GeV$/c$ pions into $\pi^-\pi^-\pi^+$ using a hydrogen target and confirm $\pi_1(1600) \to \rho(770) \pi$ amplitude, which interferes with nonresonant $1^{-+}$ amplitude. demonstrate that conflicting conclusions from previous studies on these amplitudes can be attributed to different analysis models tr...

Here we report a rare case of a Chinese female patient presenting with aortic insufficiency due to a quadricuspid aortic valve and Rho negativity. The 64-year-old woman was referred with a 1-month history of dyspnea and cough (NYHA class II). A quadricuspid aortic valve was suspected, and grade 3 aortic regurgitation was identified by transthoracic echocardiography (TTE). After admission, the A...

We establish global regularity and stability for the irrotational relativistic Euler equations with equation of state $$\bar{p}{}=K\bar{\rho }{}$$ , where $$0<K<1/3$$ small initial data in expanding direction FLRW spacetimes form $$(\mathbb R\times \mathbb T^3,-d\bar{t}{}^2+\bar{t}{}^2\delta _{ij} dx^i dx^j$$ ). This provides first case non-dust fluid stabilization by spacetime expansion rate i...

Obscurin is a large ( approximately 800-kDa), modular protein of striated muscle that concentrates around the M-bands and Z-disks of each sarcomere, where it is well positioned to sense contractile activity. Obscurin contains several signaling domains, including a rho-guanine nucleotide exchange factor (rhoGEF) domain and tandem pleckstrin homology domain, consistent with a role in rho signalin...

PURPOSE Total knee arthroplasty (TKA) successfully reduces pain, but has not achieved comparable improvements in function. We hypothesized that quadriceps strength affects performance by altering loading and movement patterns during functional tasks. METHODS Fourteen subjects with isolated, unilateral TKA were tested three months after surgery. Quadriceps strength was assessed isometrically a...