Rhabdomyosarcoma (RMS) is the most frequent pediatric soft-tissue tumor accounting for about 7% of childhood malignancies. Multimodal therapy is the standard treatment for individuals with RMS but generally fails to cure high-risk group patients and can result in long-term side effects. Therefore, understanding the mechanisms driving RMS might help to find new candidate targets for more specifi...

We report results from a new methodology for investigating the visually perceived properties of surface textures. Densely sampled two-dimensional 1/f(beta) noise processes are used to model natural looking surfaces, which are rendered using combined point-source and ambient lighting. Surfaces are shown in motion to provide rich cues to their relief. They are generated in real time to enable obs...

Real-time single- and multiple-axis vibrotactile feedback of trunk motion has been shown to significantly decrease mean trunk tilt and decrease time spent outside a no vibrotactile feedback zone (dead zone) in older adults within a laboratory setting. This study aimed to determine if these improvements can translate into everyday use, during which other tasks may simultaneously demand attention...

Open-loop adaptive optics is a technique in which the turbulent wavefront is measured before it hits the deformable mirror for correction. We present a technique to model a deformable mirror working in open-loop based on multivariate adaptive regression splines (MARS), a non-parametric regression technique. The model's input is the wavefront correction to apply to the mirror and its output is t...

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and is divided into two major histological subgroups, i.e., embryonal (ERMS) and alveolar RMS (ARMS). RMS can show HEDGEHOG/SMOOTHENED (HH/SMO) signaling activity and several clinical trials using HH inhibitors for therapy of RMS have been launched. We here compared the antitumoral effects of the SMO inhibitors GDC-0449, ...

The purpose of this study is to investigate whether medication and deep brain stimulation (DBS) have differential effects on the speed and amplitude of bradykinesia in patients with Parkinson's disease (PD). Five PD patients with implanted DBS electrodes (age: 60.6 ± 7.4 yrs, H&Y stage: 3.1 ± 0.2) participated in this study. FT (finger tapping) movement was measured using a gyrosensor system in...

Theoretical research in international trade increasingly focuses on …rm heterogeneity in di¤erentiated product markets following Melitz (2003). A key implication of this line of research is that …rms are unevenly affected by trade liberalization: low productivity …rms exit, intermediate-productivity domestic …rms contract, and high-productivity exporting …rms expand. More recent theoretical res...