The objective of this study is to assess the criteria for metastatic involvement LN (MLN) according magnetic resonance imaging (MRI) and identify most prognostically significant. MRI data 159 removed were compared with results a morphological resected preparations. ROC- analysis (Receiver Operating Characteristic curve) was used determine diagnostic performance threshold values. test evaluated ...

background: early detection is a key to survival for gastric cancer. molecular markers such as mirna (microrna) can have great importance in the early diagnosis of gastric cancer. expression of mir-21 and mir-221 are deregulated in many types of human cancers. this study aimed to investigate the differences in mirna expression patterns within the iranian population. methods: total rna was extra...

BACKGROUND Modeling studies using hypothetical polygenic risk data can be an efficient tool for investigating the effectiveness of downstream applications such as targeting interventions to risk groups to justify whether empirical investigation is warranted. We investigated the assumptions underlying a method that simulates risk data for specific values of the area under the receiver operating ...

UNLABELLED Receiver operating characteristic (ROC) analysis is usually applied in bioinformatics to evaluate the abilities of biological markers to differentiate between the presence or absence of a disease. It includes the derivation of the useful scalar performance measure area under the ROC curve for binary classification tasks. As real applications often deal with more than two classes, mul...

Sampling variability results in uncertainties of measures. The nonparametric twosample bootstrap method has been used to compute uncertainties of measures in receiver operating characteristic (ROC) analysis on large datasets, such as the standard error (SE) of the equal error rate in biometrics, the SE of a detection cost function in speaker recognition evaluation, and others. Specifically, the...

We present a new analysis for the combination of binary classifiers. Our analysis makes use of the Neyman-Pearson lemma as a theoretical basis to analyze combinations of classifiers. We give a method for finding the optimal decision rule for a combination of classifiers and prove that it has the optimal ROC curve. We show how our method generalizes and improves previous work on combining classi...

We introduce a new smooth estimator of the ROC curve based on log-concave density estimates of the constituent distributions. We show that our estimate is asymptotically equivalent to the empirical ROC curve if the underlying densities are in fact log-concave. In addition, we empirically show that our proposed estimator exhibits an efficiency gain for finite sample sizes with respect to the sta...

AIMS Lynch Syndrome is caused by mutations in DNA mismatch repair (MMR) genes. Mutation carrier identification is facilitated by immunohistochemical detection of the MMR proteins MHL1 and MSH2 in tumour tissue and is desirable as colonoscopic screening reduces mortality. However, protein detection by conventional immunohistochemistry (IHC) is subjective, and quantitative techniques are required...

-Receiver Operating Characteristic (ROC) curves are used to describe and compare the accuracy of diagnostic test or the ability of a continuous biomarker in discriminating between the subjects into healthy or diseased cases in medical field. The most familiar form of ROC curve is Bi-normal (Gaussian) ROC curve model, which assumes that the test scores or a monotone transformation of the test sc...