Background: Chlamydia (C.) trachomatis is an obligate intracellular gram-negative pathogen affecting over 600 million people worldwide with 92 million new cases occurring globally each year. Genital C. trachomatis infection has been recognized as the most common cause of pelvic inflammatory disease leading to severe tubal damage, ectopic pregnancy, hydrosalpinx and infertility. However, the mec...

Hybridization of mutant cell lines deficient in hypoxanthine-guanine phosphoribosyl transferase (HGPRT; E.C.: 2.4.2.8) from a variety of established rodent sources with HGPRT plus human cells yielded progeny cells which grew in selective medium containing hypoxanthine, aminopterin and thymidine (HAT). The same result was obtained when the human cell used was an HGPRT minus transformed line deri...

We characterized the relationship between fleas and their rodent hosts in the presence of prairie dog colonies and compared them to adjacent assemblages away from colonies. We evaluated the rodent-flea relationship by quantifying prevalence, probability of infestation, flea load, and intensity of fleas on rodents. As prairie dog burrows provide refugia for fleas, we hypothesized that prevalence...

The overall survival rate of extracorporeal life support (ECLS) remains at 60%. Research and development has been slow, in part due to the lack sophisticated experimental models. This publication introduces a dedicated rodent oxygenator (“RatOx”) presents preliminary vitro classification tests. RatOx an adaptable fiber module size for various Gas transfer performances over different blood flows...

BACKGROUND Selective disruption of the spleen tyrosine kinase (Syk) represents a novel strategy to control B-cell functional responses by inhibition of B-cell antigen receptor (BCR) signaling. PRT062607 (P505-15) is a highly selective small molecule Syk inhibitor that potently suppresses B-cell function in human and rodent blood, and reduces inflammation in rodent models of rheumatoid arthritis...

Introduction Quality Assurance/Surveillance monitoring programs used in contemporary rodent colonies are vital for prevention of clinical disease and also for prevention of adventitious infections (coming from another source) that could interfere with research. Critical decision-making about animal experimentation often relies on the quality and reliability of monitoring materials and methods. ...

Deciphering how climatic variability modulates the interspecific interactions in natural systems is one of most interesting and least studied ecological processes. Rodent outbreaks or irruptions semiarid Chile are associated with rainfall pulses driven by El Niño Southern Oscillation (ENSO). During last decade, north-central has experienced an almost uninterrupted sequence > 10 dry years, so-ca...

The history of the early Middle Pleistocene small mammal faunas Eastern Europe is very complicated. which spanned from Brunhes-Matuyama transition (772.9 ka BP, within MIS 19) till beginning Likhvin Interglacial (424 11) includes a number interglacials and glaciations. Rodent species Tiraspolian faunal assemblage were found in Chaudian fluvial deposits Cape Pekla section (northern coast Taman P...

Abstract Rodent biogeographic studies are disproportionately scarce in Iran, however, they an ideal system to understand drivers of biodiversity distributions the country. The aims present research determine (i) pattern rodent richness across country, (ii) quantify their elevational distribution patterns, and (iii) explore underlying mechanisms. To reach these goals, updated species list was co...

Rodent baits containing systemic insecticides are potential tools to interrupt the cycle of transmission of Leishmania parasites by killing sand flies that take bloodmeals from rodents as adults. Bio-indicators that can be used in conjunction with rodent-targeted sand fly control methods also have been developed to demonstrate that the insecticide treatments are reaching the targeted life stage...