Homodimerization of RON (MST1R), a receptor tyrosine kinase, usually occurs in cells stimulated by a ligand and leads to the downstream activation of signaling pathways. Here we report that bladder cancer cells, in response to physiological stress, use an alternative mechanism for signaling activation. Time-course studies indicated that RON migrated directly from the membrane to the nucleus of ...

Hepatocyte growth factor-like protein (HGFl) and its receptor, Recepteur d'Origine Nantais (RON), have been implicated in the development of wound chronicity. HGFl and RON expression was detected in acute wound tissue, chronic wound tissue and in normal skin using quantitative polymerase chain reaction (Q-PCR). HGFl and RON expression was also assessed in chronic healing and chronic non-healing...

The mammalian RON and the avian sea genes encode tyrosine kinase receptors of poorly characterized biological functions. We recently identified macrophage-stimulating protein as the ligand for Ron; no ligand has yet been found for Sea. In this work we investigated the biological response to macrophage-stimulating protein in mouse liver progenitor cells expressing Ron. These cells were also tran...

RED algorithm is a technique which has been introduced in MANETs as well as in RADNETs to avoid the congestion and contention. As compared to some of the existing mechanisms, the concept of RED algorithm is put into practice for the monitoring of traffic within the network and to avoid it in order to enhance the efficiency of the network. RED works on the basic principal of Active Queue Managem...

Initially HIV infection in Arad County was impacting infant population. Later most of the new cases were adults, but even so trends in recent years are moving in the same way for adults and children, the latter being infected through vertical transmission. The hypothesis was to determine the relationship between age of cases at diagnosis moment and route of transmission in more than two decades...

Large dynamic on-resistance due to a trap at EC-2.0 eV is observed in industry-supplied AlGaN/GaN MISHEMTs. This trap is likely in the GaN buffer and possibly related to carbon. AlGaN/GaN metal-insulator-semiconductor high electron mobility transistors (MISHEMTs) for high voltage switching applications are promising due to the ability to simultaneously achieve high breakdown voltage and low on-...

PURPOSE The receptor tyrosine kinase RON is critical in epithelial tumorigenesis and a drug target for cancer therapy. Here, we report the development and therapeutic efficacy of a novel anti-RON antibody Zt/g4-maytansinoid (DM1) conjugates for targeted colorectal cancer (CRC) therapy. EXPERIMENTAL DESIGN Zt/g4 (IgG1a/κ) was conjugated to DM1 via thioether linkage to form Zt/g4-DM1 with a dru...

PURPOSE Recent studies have demonstrated that short-form Ron (sfRon) kinase drives breast tumor progression and metastasis through robust activation of the PI3K pathway. We reasoned that upfront, concurrent inhibition of sfRon and PI3K might enhance the antitumor effects of Ron kinase inhibitor therapy while also preventing potential therapeutic resistance to tyrosine kinase inhibitors (TKI). ...