The structure of prescriptions cardiac drugs by the primary care physicians has remained unknown for a long time. We decided to use data OZIRKA study, which aimed investigate effect Ozalex (rosuvastatin) on lipid and cholesterol levels in patients with metabolism disorders hypercholesterolemia, assess real clinical practice, as well effectiveness cardiovascular risk factors monitoring. sincerel...

Abstract The aim of this study was to evaluate the effects increasing concentrations three pure statins on in vitro methane production and rumen fermentation. atorvastatin, rosuvastatin simvastatin at (1, 10, 100 mg/L culture fluid) were evaluated using 24 h batch incubation buffered fluid with a 70:30 forage:concentrate substrate. All tested demonstrated ability reduce methanogenesis. Methane ...

The Efficacy of Atorvastatin and Rosuvastatin on the Changes alpha beta Apolipoproteins; A Systematic Review Meta-Analysis

Correspondence: Ferruccio De Lorenzo Consultant Physician, General Medicine and Prevention of Vascular Disorders, Beta Cell Diabetes Centre and St Stephen’s AIDS Trust, Chelsea and Westminster Hospital NHS Foundation Trust, 369 Fulham Road, London SW10 9NH, UK Email [email protected] Investigational product: Rosuvastatin (Crestor; Astra Zeneca). Active ingredients: Rosuvastatin (5 mg). Study ...

Statins reduce cardiovascular morbidity and mortality with dyslipidemia. Although generally well‑tolerated, dose‑dependent adverse events develop in 10%–15% patients. In addition, up to 3% patients have mildly elevated serum aminotransferase levels within the 1 st year of therapy that are rarely associated with symptoms. We report a case of clinically significant hepatotoxicity after a very bri...

Hypercholesterolemic patients (n = 1,547) at high atherosclerotic cardiovascular disease risk with low-density lipoprotein cholesterol (LDL-C) levels ≥100 and ≤160 mg/dl while treated with atorvastatin 10 mg/day entered a multicenter, randomized, double-blind, active-controlled, clinical trial using two 6-week study periods. Period I compared the efficacy/safety of (1) adding ezetimibe 10 mg (e...

BACKGROUND The effectiveness of lipid-lowering medication critically depends on the patients' compliance and the efficacy of the prescribed drug. OBJECTIVES The primary objective of this multicentre study was to compare the efficacy of rosuvastatin with or without access to compliance initiatives, in bringing patients to the Joint European Task Force's (1998) recommended low-density lipoprote...

Methods A cohort of 17,802 apparently healthy men and women with high-sensitivity C-reactive protein 2 mg/l and LDL-C 130 mg/dl were randomly allocated to rosuvastatin 20 mg daily or placebo, and followed up for allcause mortality, major cardiovascular events, and adverse events. In a post-hoc analysis, participants allocated to rosuvastatin were categorized as to whether or not they had a foll...

This paper presents a case of reversible dysphasia occurring in a patient prescribed atorvastatin in combination with indapamide. A milder dysphasia recurred with the prescription of rosuvastatin and was documented on clinical examination. This resolved following cessation of rosuvastatin. The case highlights both a need for a wider understanding of potential drug interactions through the CYP 4...

An observational study and a "clinical trial" seem to prove that rosuvastatin (but not fluvastatin) dramatically increases serum levels of 25-(OH)-D3 (three-fold above starting values). A critical analysis of the two publications, presented below, raises serious concerns. Conclusions from these two studies have already been drawn in the scientific literature.It is argued that claiming or believ...