Smoking is the most common route of administration for cannabis; however, vaping cannabis extracts and synthetic cannabinoids ("fake marijuana") in electronic cigarette devices has become increasingly popular. Yet, most animal models used to investigate biological mechanisms underlying cannabis use employ injection as the route of administration. This study evaluated a novel e-cigarette device ...

INTRODUCTION The intraosseous (IO) route has become a popular method to gain access to the peripheral circulation in emergency situations. Despite little supporting data, it is generally believed that IO absorption is immediate and equivalent to the intravenous (IV) route. It is important to determine if rocuronium can effectively be administered by the IO route. The aim of the study was to det...

The influence in immunization with cholera toxin of the route and antigen dose on intestinal antibody formation and protective immunity against experimental cholera was studied in mice. Administration by either the intravenous or oral route induced effective priming as well as boosting of mucosal immunity, with the effects on intestinal immunoglobulin A antitoxin synthesis and protective antito...

Background: There is extensive variety of chemical compounds with antiulcer activity, which are isolated from medicinal plants. Matricaria chamomilla or Matricaria recutita or German chamomile, also spelled chamomile (MC), is one of the most widely used medicinal plants. In the present study, the extract of MC flowers was evaluated for antiulcerogenic activity and acute toxicity profile. Method...

There were many natural pharmaceutical dosage forms cited by Persian pharmacists and physicians in the historical pharmacopeias (Qarabadins). This work aimed to perform a comprehensive study on “Qarābādin-e-Sālehi” (1765 A.D.), one of the main Persian pharmaceutical manuscripts defining traditional dosage forms. All traditional dosage forms as well as their definitions, descri...