Nitric oxide (NO) production by neurons in the prepositus hypoglossi (PH) nucleus is necessary for the normal performance of eye movements in alert animals. In this study, the mechanism(s) of action of NO in the oculomotor system has been investigated. Spontaneous and vestibularly induced eye movements were recorded in alert cats before and after microinjections in the PH nucleus of drugs affec...

A 32-year-old man planned to have laser in situ keratomileusis (LASIK) in both eyes. The preoperative manifest refraction was 6.50 + 1.00 80 in the right eye and 6.25 + 1.00 90 in the left eye, yielding a visual acuity of 20/20 in both eyes. Topography was normal. Ultrasound pachymetry was 581 mm in the right eye and 574 mm in the left eye. The LASIK procedure was performed with a femtosecond l...

3 Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio. *A listing of the Comparison of Age-Related Macular Degeneration Treatments Trials Research Group is available at www.aaojournal.org. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article. Supported by the National Eye Institute, National Institutes of Health, Bethesda...

We analyzed gaze shifts made by trained rhesus monkeys with completely unrestrained heads during performance of a delayed gaze shift task. Subjects made horizontal, vertical, and oblique gaze shifts to visual targets. We found that coordinated eye-head movements are characterized by a set of lawful relationships, and that the initial position of the eyes in the orbits and the direction of the g...

A 50-year-old man with a history of protein S deficiency treated by long-term warfarin presented with right non-arteritic optic neuropathy. Following successful augmentation of warfarin to minimise the effect of thrombophilia, he had a recurrence in the right eye and involvement of the left eye 11 days after the initial onset. Further investigation showed a marginal blood lipid profile, which w...

The retinal projection to the superior colliculus is thought to be important both for stimulus-driven eye movements and for the involuntary capture of attention. It has further been argued that eye-movement planning and attentional orienting share common neural mechanisms. Electrophysiological studies have shown that the superior colliculus receives no direct projections from short-wave-sensiti...

Introduction: Based on the invasive studies it has been shown that factors such as age, the progress of eye disorders, lens fibers compression and the biochemical changes of ocular matrix alter the physical characteristics and elastic properties of eye. In this study, a noninvasive method of estimating human eye elasticityis proposed and its relation with age and gender is evaluated using ultra...

There is considerable interest in new methods for the assessment of retinal blood flow for the diagnosis of eye diseases. We present in vivo normal human volumetric retinal flow measurement using Fourier domain Doppler optical coherence tomography. We used a dual-plane scanning pattern to determine the angle between the blood flow and the scanning beam in order to measure total flow velocity. V...

PURPOSE To assess the possible effects of retinal prosthesis implant location on the initiation and stability of pursuit eye movements. METHODS Six normally sighted subjects visually tracked a horizontally moving target in natural vision and in simulated prosthetic vision. Subjects were instructed to press a key when the target jumped. Prosthetic vision was simulated with a 10 x 10 array of 1...

We studied the effect of cerebellar lesions on the 3-D control of the rotational vestibuloocular reflex (RVOR) to abrupt yaw-axis head rotation. Using search coils, three-dimensional (3-D) eye movements were recorded from nine patients with cerebellar disease and seven normal subjects during brief chair rotations (200 degrees /s(2) to 40 degrees /s) and manual head impulses. We determined the a...