BACKGROUND Stunted development and reduced fecundity of Schistosoma parasites in immunodeficient mice and the impaired ability of human immunodeficiency virus 1 (HIV-1)-infected humans to excrete schistosome eggs have been described. This study explores the effect that HIV-1-associated immunodeficiency has on the excretion of schistosome eggs in a large cohort of coinfected individuals. METHO...

Objective: Grade three children (9-10 years) are recommended as the optimal study population for assessing community prevalence of schistosomiasis and soil transmitted helminthiasis (STHs).However their knowledge, attitudes and practices (KAP) of these children in relation to schistosomiasis, and malaria is not known. Methods: Using multistage sampling, grade 3 children (n=172) were randomly se...

Background: Schistosoma mansoni was observed and reported in Kuluva hospital Arua District in north western Uganda as early as 1902. S. mansoni is widely distributed in Uganda along permanent water bodies. Objective: To review the litreture on scistosomiasis in Uganda, since 1902. Method: The core literature for this short review was searched from reports and publications by the British colonia...

There is an urgent need for information on schistosomiasis in preschool children, who are often excluded in mass treatment programmes. The prevalence and intensity of Schistosoma haematobium infection were determined in preschool children aged ≤ 6 years in two rural communities in Ijebu East, south-western Nigeria. Two urine samples each were collected from 83 preschool children from the two co...

In a Schistosoma haematobium-endemic village in western Madagascar we evaluated ultrasonography and Eosinophil Cationic Protein (ECP) in urine as means to detect the associated urinary tract pathology. 192 individuals were matched according to age and sex, and grouped into infected persons with bladder and, if present, kidney pathology (n = 96); infected persons without pathology (n = 48) and n...

Urinary schistosomiasis remains a significant burden for Africa and the Middle East. The success of population-based control programs will depend on their impact, over many years, on Schistosoma haematobium reinfection and associated disease. In a multi-year (1984-1992) control program in Kenya, we examined risk for S. haematobium reinfection and late disease during and after annual school-base...

Urological abnormalities caused by Schistosoma haematobium are apparently common in East, West and Central Africa. A community of 1074 persons living in an area of endemic urinary schistosomiasis in rural Zanzibar, Tanzania, was studied for 2 years to determine the importance of these abnormalities and how they affected patients' health.Of the total community, 1004 persons (93.5%) were examined...

BACKGROUND Chronic schistosomiasis is associated with T cell hypo-responsiveness and immunoregulatory mechanisms, including induction of regulatory T cells (Tregs). However, little is known about Treg functional capacity during human Schistosoma haematobium infection. METHODOLOGY CD4+CD25hiFOXP3+ cells were characterized by flow cytometry and their function assessed by analysing total and Tre...

a two-year laboratory study on the biology (including self-fertilization) of bulinus truncatus, the intermediate host of schistosoma haematobium, s. bovis and paramphistomum microbotrium in iran, has revealed information on the longevity, reproduction, hatchability rate, hatching time during various months of the year, and growth and mortality rates of this snail. it was found that the reproduc...

Urogenital schistosomiasis, caused by the parasitic trematode Schistosoma haematobium, affects over 112 million people worldwide. As with S. mansoni infections, the pathology in urogenital schistosomiasis is mainly related to the egg stage, which induces granulomatous inflammation of affected tissues. Schistosoma eggs and their secretions have been studied extensively for the related S. mansoni...