نتایج جستجو برای: s tnf

تعداد نتایج: 761629  

Journal: :The Journal of Experimental Medicine 1993
C Caux I Durand I Moreau V Duvert S Saeland J Banchereau

We have recently demonstrated that tumor necrosis factor alpha (TNF-alpha) potentiates interleukin 3 (IL-3) and granulocyte/macrophage colony-stimulating factor-induced growth of CD34+ hematopoietic progenitor cells (HPC), and favors the generation of dendritic/Langerhans cells. The stimulatory effect of TNF-alpha was detailed in the present study. Thus, CD34+ HPC entering in cycle (S/G2M) afte...

دستمالچی, سیاوش, فرج‌زاده, داود, کریمی‌قریق, صدیقه,

Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine produced by a variety of cells, including hematopoietic and non-hematopoietic cells, malignant cells, macrophages, B lymphocytes, T lymphocytes, natural killer cells, neutrophils, astrocytes, endothelial cells, and smooth muscle cells. TNF-α is a homo-trimeric molecular whose individual subunits are composed of antiparallel beta...

2004
Gerald Messer Elisabeth H. Weiss Patrick A. Baeuerle

The expression of the gene encoding tumor necrosis factor /3 (TNF-P) (lymphotoxin) is induced in T cells by various extracellular stimuli. We noticed that most such stimuli also activate the NF-KB transcription factor. Here we demonstrate binding of purified human NF-KB to a sequence within positions 98 to -88 (S-GGGGCTTCCCC-3’) of the TNF-P promoter, which is conserved between the human and mo...

Journal: :iranian journal of cancer prevention 0
shaghayegh amirijavid dept. of biology, science and research branch, islamic azad university, tehran, iran national science foundation (insf), tehran, iran mehrdad hashemi dept. of genetics, tehran medical sciences branch, islamic azad university, tehran, iran

1. dept. of biology, science and research branch, islamic azad university, tehran, iran 2. national science foundation (insf), tehran, iran 3. dept. of genetics, tehran medical sciences branch, islamic azad university, tehran, iran                                   corresponding author: mrhrdad hashemi, phd; associate professor of molecular genetics tel: (+98) 2122006664 email: mhashemi@iautmu....

2017
Gia Deyab Ingrid Hokstad Jon Elling Whist Milada Cvancarova Småstuen Stefan Agewall Torstein Lyberg Barbara Bottazzi Pier Luigi Meroni Roberto Leone Gunnbjorg Hjeltnes Ivana Hollan

BACKGROUND Pentraxin 3 is proposed to be a marker of inflammation and cardiovascular risk, but its role in inflammatory rheumatic diseases (IRDs) is still uncertain. Therefore, we wanted to examine if anti-rheumatic treatment reduced serum PTX3 (s-PTX3) levels in IRDs, and if s-PTX3 levels were related to other markers of inflammation and to endothelial function (EF). METHODS We examined s-PT...

2009
Ying-Chi Lin Patrick M. Schlievert Michele J. Anderson Christina L. Fair Matthew M. Schaefers Ramaiah Muthyala Marnie L. Peterson

BACKGROUND Glycerol monolaurate (GML), a 12 carbon fatty acid monoester, inhibits Staphylococcus aureus growth and exotoxin production, but is degraded by S. aureus lipase. Therefore, dodecylglycerol (DDG), a 12 carbon fatty acid monoether, was compared in vitro and in vivo to GML for its effects on S. aureus growth, exotoxin production, and stability. METHODOLOGY/PRINCIPAL FINDINGS Antimicro...

Journal: :American journal of physiology. Renal physiology 2005
R A Zager Ali C M Johnson Sherry Y Hanson Steve Lund

Endotoxemia (LPS) can exacerbate ischemic tubular injury and acute renal failure (ARF). The present study tested the following hypothesis: that acute ischemic damage sensitizes the kidney to LPS-mediated TNF-alpha generation, a process that can worsen inflammation and cytotoxicity. CD-1 mice underwent 15 min of unilateral renal ischemia. LPS (10 mg/kg iv), or its vehicle, was injected either 45...

2010
Adam A. Anas Joppe W. R. Hovius Cornelis van 't Veer Tom van der Poll Alex F. de Vos

BACKGROUND Recognition of lipopolysaccharide (LPS) is required for effective defense against invading gram-negative bacteria. Recently, in vitro studies revealed that CD14 is required for activation of the myeloid differentiation factor (MyD)88-dependent Toll-like receptor (TLR)4 signaling pathway by smooth (S)-LPS, but not by rough (R)-LPS. The present study investigated the role of CD14 in in...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده علوم 1389

مولتیپل اسکلروزیس (ms) یک بیماری عصبی با واسطه ایمنی است که در آن از بین رفتن میلین سلولهای عصبی روی می دهد و بیماری فرساینده دستگاه عصبی مرکزی(cns) است. هیچ آنتی ژن هدف مخصوصی که به وسیله سیستم ایمنی بیماران ms مورد حمله قرار گیرد هنوز شناخته نشده است. علت بیماری ms هنوز شناخته شده نیست. عقیده بر این است که این بیماری با فاکتورهای میکروبی، ژنتیکی و یا محیطی ارتباط دارد. مولتیپل اسکلروزیس به عن...

Journal: :The Journal of Experimental Medicine 1989
H Gerlach H Lieberman R Bach G Godman J Brett D Stern

Some in vivo observations have suggested that growing or perturbed endothelium, such as that which occurs during angiogenesis, is more sensitive to the action of cytokines (TNF/cachectin, TNF, or IL-1) than normal quiescent endothelial cells. This led us to examine the responsiveness of endothelium to TNF as a function of the growth/motile state of the cell. TNF-induced modulation of endothelia...

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