Objective(s):The aim of this study was to investigate the effects of nutritional saffron (Crocus sativus L.) stigma hydroalcoholic extract on blood pressure (BP) and histology of the aorta in normotensive and hypertensive rats. Materials and Methods:   Saffron (200 mg/kg/day) was given orally for 5 weeks to normotensive and hypertensive rats. Hypertension was induced by NG-nitro-L-arginine meth...

background: saffron (crocus sativus l.) is a common but very expensive herbal medicine. as an important traditional medicine, it has an outstanding effect in treating irregular and painful menstruation. recently, the over-demand tendency of saffron results in an unusual phenomenon in the medicinal markets. adulterants and saffron-like substitutes are intentionally mixed into medicinal markets a...

safranal, the main component of crocus sativus essential oil, exhibits different pharmacological activities. in this study, the effects of safranal, on blood pressure of normotensive and desoxycorticosterone acetate (doca) - salt induced hypertensive rats in chronic administration were investigated. three doses of safranal (1, 2 and 4 mg/kg/day) and spironolactone (50 mg/kg/day) were administra...

background: saffron is the dried stigmata of the flowers of saffron (crocus sativus l., iridaceae). saffron and its major active constituents, crocin (crocetin glycoside), crocetin and safranal, have a variety of pharmacological effects including high antioxidant properties and crocetin has insulin sensitizing effect possibly due to its antioxidant activity. oral crocin is not absorbed and is h...

Although it is well established that chronic stress impairs spatial learning and memory, few studies have investigated possible ways to prevent its deleterious effects. Here, we investigated the effects of Crocus sativus L., commonly known as saffron, and its active constituent crocin on learning and memory loss and the induction of oxidative stress in the hippocampus by chronic stress. Rats we...

PURPOSE Chronic stress has been reported to induce oxidative damage of the brain. A few studies have shown that Crocus Sativus L., commonly known as saffron and its active constituent crocin may have a protective effect against oxidative stress. The present work was designed to study the protective effects of saffron extract and crocin on chronic - stress induced oxidative stress damage of the ...

the acute and sub-acute toxicity of safranal were studied in rat and mice within 2 and 21 days after exposure, respectively. for subacute toxicity, changes in weight as well as biochemical, hematological and pathological parameters were studied. the intraperitoneal ld50 values of safranal were 1.48 ml/kg in male mice, 1.88 ml/kg in female mice and 1.50 ml/kg in male rats. oral ld50 values were ...

objective(s): crocin is the chemical ingredient primarily responsible for the color of saffron. it has different pharmacological effects such as antioxidant, anticancer and memory improving activities. crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. materials and methods: the study was a randomized, double-blind, placebo-controlled design consis...