Background: Basal energy requirements are higher in adolescents with sickle cell anemia (SCA) than in healthy control subjects. However, no equation is available to accurately predict their energy needs. Objective: Our objective was to develop a clinically useful equation to estimate resting energy expenditure (REE) in adolescents with SCA. Design: REE and other components of total energy expen...

Inflammation, cell adhesion to vascular endothelium, and endothelial injury contribute to sickle cell anemia (SCA) vaso-occlusion. Although alterations in inflammatory cytokines and biomarkers have been related, reports have been conflicting, and a conclusive role for these molecules in the disease remains to be established. Furthermore, the effect of hydroxyurea therapy (HU) on the release of ...

Introduction Chronic kidney disease (CKD) patients have increased risks of sudden cardiac arrest and sudden cardiac death (SCA/SCD) that are not explained by traditional risk factors. We examined associations between serum potassium and SCA/SCD in a large cohort of patients with coronary artery disease (CAD) and moderate CKD. Methods Among 22,009 patients who underwent cardiac catheterization...

UNLABELLED BACKGROUND Sickle cell anaemia (SCA) is a major chronic health problem in Uganda. In patients with SCA, the level of foetal haemoglobin (HbF) has been found to be important in influencing the clinical course of the disease. Thus populations with high levels of HbF like those in Saudi Arabia have been described as having a milder clinical course with fewer complications as compared...

Sudden cardiac arrest (SCA) is a major cause of mortality in North America and other westernized societies, accounting for 10% of all deaths and up to 50% of heart disease–related death.1,2 The condition is characterized by an unexpected cardiovascular collapse due to an underlying cardiac cause.3 This definition, although useful as an intellectual foundation, is challenged by operational trans...

Surface proteins of the obligate intracellular bacterium Rickettsia typhi, the agent of murine or endemic typhus fever, comprise an important interface for host-pathogen interactions including adherence, invasion and survival in the host cytoplasm. In this report, we present analyses of the surface exposed proteins of R. typhi based on a suite of predictive algorithms complemented by experiment...

BACKGROUND In systems biology it is common to obtain for the same set of biological entities information from multiple sources. Examples include expression data for the same set of orthologous genes screened in different organisms and data on the same set of culture samples obtained with different high-throughput techniques. A major challenge is to find the important biological processes underl...

BACKGROUND Basal energy requirements are higher in adolescents with sickle cell anemia (SCA) than in healthy control subjects. However, no equation is available to accurately predict their energy needs. OBJECTIVE Our objective was to develop a clinically useful equation to estimate resting energy expenditure (REE) in adolescents with SCA. DESIGN REE and other components of total energy expe...

Problem statement: This study presents an in-depth analysis of the performance of Software Communications Architecture (SCA) component-based waveform applications in terms of inter-component communications. The main limitation with SCA, in the context of embedded systems, is the additional cost introduced by the use of Object Request Broker (ORB) middleware. The ORB middleware handles the inter...

The risk and clinical significance of cardiac iron overload due to chronic transfusion varies with the underlying disease. Cardiac iron overload shortens the life expectancy of patients with thalassemia, whereas its effect is unclear in those with myelodysplastic syndromes (MDS). In patients with sickle cell anemia (SCA), iron does not seem to deposit quickly in the heart. Our primary objective...