Objective(s):Diabetic neuropathy (DN) is a common complication of diabetes that leads to allodynia, impaired nerve conduction, and progressive sensory loss. The aim of this study was to observe the effect of a high-affinity cannabinoid receptors agonist, WIN 55,212-2, on thermal hyperalgesia, nerve conduction velocity and sciatic nerve histopathology in diabetic rats. Materials and Methods: Di...

A 59-year-old man with knee arthritis suddenly developed left posterior thigh pain and complete paralysis of his foot. EMG/nerve conduction studies localized the lesion to the distal sciatic nerve in the thigh (absent motor units from the short head of biceps femoris but normal vastus lateralis). Imaging demonstrated an intraneural ganglion cyst in the tibial nerve extending up to the sciatic n...

objective(s):based on the previous reports, silymarin can suppress nitric oxide, prostaglandin e2 (pge2), leukotrienes, cytokines production, and neutrophils infiltration. regarding the fact that inflammation plays an important role in neuropathic and formalin-induced pain, it was assumed that silymarin could reduce pain. the present study investigates the analgesic effects of silymarin in chem...

Neurotrophins are a group of nerve growth factors with their protein structure. These proteins play an important role in the growth and metabolism of many cells and maintain nerve, muscle, synaptic potentials, and also helps reduce depression and apoptosis. The aim of this study was to evaluate the effect of 10 weeks low-intensity aerobic training and limited blood flow to the amount of protein...

Objective- To studylocal effect of prostaglandin E1on sciatic nerve regeneration Design- Experimental study Animals- Sixty male healthy white Wistar rats Procedures- Sixty animals were divided into four experimental groups (n = 15), randomly: Trasnsected (TC), Sham-operation (SHAM), control (CHIT) and prostagl...

Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstrated, whether tau is involved in peripheral nerve regeneration remains unknown. In the current study, we obtained sciatic nerve tissue from adult r...

With great interest, we read the article by Prakash et al, entitled “Sciatic nerve division: a cadaver study in the Indian population and review of the literature”.(1) A total of 86 inferior extremities were dissected in order to expose the sciatic nerve, including its division into the tibial and common peroneal nerves. First, we would like to commend the authors for emphasising the issue of s...

Sciatic nerve injury is a common disease of peripheral nerve in clinic. After nerve injury, there are many dysfunctions in motoneurons and muscles following regeneration. Previous studies mostly investigated the aspects related to the injured nerve, and the effect on the recurrent inhibition (RI) pathway of spine following regeneration was not fully understood. Following reinnervation after tem...

Intramuscular drug injection in the gluteal region is often the most frequent cause of sciatic nerve injury in preterm newborns. Local anatomic variation is one of the predisposing causes of iatrogenic sciatic nerve injury. The aim of this morphological study was to assess the relationship of sciatic nerve with the piriformis muscle and to elucidate variations of fusion of piriformis with neigh...

We investigated the effect of leg position on the depth of the sciatic nerve and quality of ultrasound images taken at the proximal and mid-thigh level. Twenty-one volunteers with average body mass index were recruited to represent the younger population receiving sciatic nerve blocks for sports injury surgery. The volunteers were placed in the lateral position, with the hip flexed and with the...