Rosai-Dorfman disease (RDD) also known as sinus histiocytosis with massive lymphadenopathy is a rare disorder of histiocytes characterized histologically by intracellular engulfment lymphocytes. It may occur in any age group, but most commonly seen children and young adults. painless, bilateral cervical lymphadenopathy. In approximately one-third patients it can variety extranodal sites where h...

a bstract       background:  patients with multiple sclerosis experience hospitalization several times in their lives. certainly, providing ef fi cient and high-quality care by healthcare professionals is not possible unless the experiences of patients’ hospitalization are taken into consideration. this qualitative study was aimed to identify experiences of patients with multiple sclerosis in t...

To the editor: In their article on multiple sclerosis (Can Med Assoc J 1982; 126: 377-382, 385) the most recent reference Warren and coworkers cite on familial predisposition to multiple sclerosis is 19 years old.' This gives the false impression that no recent work has been done in this area. I would like to report some recent studies conducted in British Columbia on the genetic aspects of mul...

Mutations in the gene superoxide dismutase 1 (SOD1) are causative for familial forms of the neurodegenerative disease amyotrophic lateral sclerosis. When the first SOD1 mutations were identified they were postulated to give rise to amyotrophic lateral sclerosis through a loss of function mechanism, but experimental data soon showed that the disease arises from a--still unknown--toxic gain of fu...

An increased risk of multiple sclerosis among smokers has been found in several prospective epidemiological studies. The association between smoking and progression of multiple sclerosis has not been examined. We identified patients who had a first multiple sclerosis diagnosis recorded in the General Practice Research Database (GPRD) between January 1993 and December 2000. Their diagnosis and d...

Baló's concentric sclerosis is a rare atypical form of multiple sclerosis characterized by striking concentric demyelination patterns. We propose a robust mathematical model for Baló's sclerosis, sharing common molecular and cellular mechanisms with multiple sclerosis. A reconsideration of the analogies between Baló's sclerosis and the Liesegang periodic precipitation phenomenon led us to propo...

Systemic sclerosis or scleroderma is a rare autoimmune disorder characterized by excessive fibrosis and, vasculopathy, with multiorgan involvement. Anesthetic considerations in patients with systemic sclerosis must take into account the degree of organ dysfunction as well as airway management. Regional anesthesia is a preferable alternative to general anesthesia despite the reports of prolonged...