1. Chang WH. Current status of tsutsugamushi disease in Korea. J Korean Med Sci. 1995;10:227–38. 2. Cook GC, Warrell DA, Bryceson AD. Royal Society of Tropical Medicine and Hygiene meeting at Manson House, London, 17 October 1996. Debate: tropical medicine as a formal discipline is dead and should be buried. Trans R Soc Trop Med Hyg. 1997;91:372–4, discussion 374–5. DOI: 10.1016/S0035-9203(97)9...

Scrub typhus is caused by Orientia tsutsugamushi. Any delay in diagnosis can result in delayed treatment and severe complications, including secondary hemophagocytic lymphohistiocytosis, which is rare but potentially fatal. In this paper, the authors present 3 cases of secondary hemophagocytic lymphohistiocytosis associated with scrub typhus, successfully treated with chloramphenicol without ad...

chills and rigors, headache, vomiting, cough which are all non-specific. Out of all the patients with pyrexia of intermediate duration studied, 10 had hepatosplenomegaly and only 1 scrub typhus positive patient had the sign and 1 out of the total 92 patients had neck stiffness and he was positive for scrub typhus by PCR. None of them had an eschar which is supposed to be characteristic of ricke...

BACKGROUND Despite increased identification of spotted fever group rickettsioses (SFGR) in animals and arthropods, human SFGR are poorly characterized in Taiwan. METHODS Patients with suspected Q fever, scrub typhus, murine typhus, leptospirosis, and dengue fever from April 2004 to December 2009 were retrospectively investigated for SFGR antibodies (Abs). Sera were screened for Rickettsia ric...

BACKGROUND The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus. METHODS From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least ...

We assessed the clinical usefulness of immunohistochemical staining on skin biopsy specimens for the diagnosis of scrub typhus compared with indirect immunofluorescent antibody assay (IFA), the definitive diagnostic method for scrub typhus, in a prospective study of 125 patients with possible scrub typhus in 2005 and 2006. Skin biopsy specimens were obtained from 63 patients. To minimize the ef...

OBJECTIVES The purpose of this study was to establish a basis for improving or strengthening the preventive strategy against scrub typhus in Korea by comparing and analyzing the difference of prevention behaviors contributing to the occurrence of scrub typhus in Japan and Korea. METHODS The survey was carried out in Jeollabuk-do, which is a high risk and high incidence area, and Fukuoka Prefe...

PURPOSE To develop a simple risk-scoring system to forecast scrub typhus severity. PATIENTS AND METHODS Seven years' retrospective data of patients diagnosed with scrub typhus from two university-affiliated hospitals in the north of Thailand were analyzed. Patients were categorized into three severity groups: nonsevere, severe, and dead. Predictors for severity were analyzed under multivariab...

Serum transcobalamin II levels were measured in scrub typhus patients. Eighteen out of fifty-two patients admitted to Maharat Nakhon Ratchasima Hospital were diagnosed with scrub typhus infection. The serum unsaturated vitamin B12 binding protein (UBBC) and total vitamin B12 binding protein (TBBC) levels in these patients were significantly higher than in normal subjects (p<0.001). The mean ser...