OBJECTIVE ACE inhibitors delay the progression from incipient to overt diabetic nephropathy and reduce albumin excretion rate (AER), independently of blood pressure. Angiotensin II type 1 receptor antagonists produce similar effects on microalbuminuria and mean arterial pressure. The aim of this study was to evaluate the effect of irbesartan on microalbuminuria and blood pressure in hypertensiv...

Microalbuminuria is a risk factor for renal and cardiovascular disease. A role for insulin resistance in the pathogenesis of microalbuminuria has been suggested but is still unproven. In this case-control, cross-sectional study, we compared glucose disposal rate (GDR), measured by hyperinsulinemic-euglycemic clamp, in 50 pairs of matched type 2 diabetic patients with micro- or normoalbuminuria ...

OBJECTIVE To evaluate the 24-h blood pressure profile in normoalbuminuric type 2 diabetic patients. RESEARCH DESIGN AND METHODS A cross-sectional study was conducted in 90 type 2 diabetic patients with a urinary albumin excretion rate (UAER) <20 microg/min on two occasions, 6 months apart (immunoturbidimetry). Patients underwent clinical and laboratory evaluations. Ambulatory blood pressure m...

Activation of several neurohormonal systems occurs during acute myocardial infarction (AMI) and is associated with short- and long-term outcomes. In the last few years, many circulating factors have received close attention but it is not clear which are the best prognostic indicators of mortality. Renin and natriuretic cardiac peptides appeared to be strong predictors of outcome in patients wit...

A slightly elevated urinary albumin excretion rate (UAER) is a predictor of atherosclerotic cardiovascular disease. The mechanism is unknown, but moderate office blood pressure elevation has been demonstrated as part of a clustering of known atherosclerotic risk factors in subjects with elevated UAER. Because 24-hour ambulatory blood pressure is a superior predictor of hypertensive target organ...

Using liquid chromatography, we estimated the urinary excretion of20a-dihydrocortisol (20-DH)and urinary freecortisol (UFC)innormalsubjects and in40 patients withCushing’s syndrome of different etiologies. The median normal excretion rate (nmol/24 h) was 174 for 20-DH and 68 for UFC, the 20-DH/UFC ratio thus being 2.55. For patients with Cushing’s syndrome, the excretion rate was 1798 for 20-DH...

BACKGROUND Acne vulgaris has been linked to the Western diet. Hyperglycemic diet increases insulin and insulin-like growth factor (IGF)-1. Deeper insights into IGF-1-mediated signal pathway are critical importance to understand the impact of Western diet. OBJECTIVE We investigated the effect of IGF-1 on the expression of inflammatory biomarkers and sebum production in cultured sebocytes. ME...

5-Methyltryptophan-resistant mutants derived from Bacillus subtilis strain 168 synthesize all of the tryptophan biosynthetic enzymes constitutively and excrete tryptophan. These mutants can be divided into three classes: class 1, low enzyme level and low rate of tryptophan excretion; class 2, high enzyme level and intermediate rate of tryptophan excretion; and class 3, high enzyme level and hig...

Acne vulgaris (AV) is the most common and multifactorial skin disease in adolescents affecting pilosebaceous unit that involves hormonal imbalance, increased sebum production, bacterial colonization, which causes both physical psychological disorders. Cutibacterium acnes considered one of key contributing factors even though many colonies are on healthy skin. induces lipogenesis production sebu...