A host-vector system for inducible secretion during the logarithmic growth phase in Bacillus subtilis has been developed. The B. subtilis levansucrase gene promoter and the region encoding its signal sequence have been used. The endoglucanase A of Clostridium thermocellum was used as a model protein to test the efficiency of the system. Effective inducible secretion of the endoglucanase A was o...

Gut microbiota contribute to host metabolic efficiency by increasing energy availability through the fermentation of dietary fiber and production of short-chain fatty acids (SCFAs) in the colon. SCFAs are proposed to stimulate secretion of the proglucagon (Gcg)-derived incretin hormone GLP-1, which stimulates insulin secretion (incretin response) and inhibits gastric emptying. We find that germ...

It has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. We have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of D-glucose. Present study was designed to investigate whether intragastric D-glucose influences gastric acid secretion associated with carbachol ...

Dark is a generally known potent stimulus for melatonin secretion. Studies have also reported that pineal and hypophyseal endocrine secretions are influenced by nutritional factors. The study was designed to investigate the combined effect of selenium supplementations and light deprivation on pineal and hypophyseal secretions in female Wistar rats. 36 female cyclical Wistar rats were divided in...

introduction: recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. it has many physiological and pharmacological roles in the human body. the aim of the present study was to investigate the effect of exogenously administered and endogenously produced h2s on the basal and distention-induced gastric acid secretion in rats. methods: forty-nine male wistar rat...

it has been shown that enhanced acid secretion can be suppressed in the rat by systemic administration of glucose. we have recently reported that enhancement of acid secretion as a result of pentagastrin was diminished by intragastric administration of d-glucose. present study was designed to investigate whether intragastric d-glucose influences gastric acid secretion associated with carbachol ...

background leptin and adiponectin are two hormones, which are released from adipocytes in order to control energy expenditure. both hormones are also involved in glucose homeostasis through control of insulin secretion from pancreatic islets. since pdx1, pparγ, and foxm1 play important roles in islets function, it is essential to understand how these genes are regulated in the islets of langerh...

Targeting of T cell epitopes to APC enhances T cell responses. We used an APC-specific Ab (anti-IgD) and substituted either of 18 loops connecting beta strands in human IgG constant H (C(H)) domains with a characterized T cell peptide epitope. All Ab-epitope fusion molecules were secreted from producing cells except IgG-loop 2(BC)C(H)1, and comparing levels, a hierarchy appeared with fusions in...

The article presents the theoretical basis of effect electrical pulse processing on process obtaining juice from grapes and fruits. High-voltage pulsed technology for biological products has a higher damaging living cells than other effects, this can be achieved due to passage large discharges current through tissues in short period time. It been found that high efficiency killing by secretion ...

The field of intestinal physiology has been transformed by the discovery that nutrient-sensitive chemosensors are strategically positioned within the gastrointestinal tract to regulate nutrient absorption and gut hormone secretion. It is well established that the composition of the diet modulates the absorptive capacity of the intestine and the secretion of gut peptides including glucoinsulinot...